Prelude Therapeutics Inc
PRLD · Pharmaceutical Preparations · 79.6M shares · +18%/yr ↑ dilution · EDGAR filings ↗
Reference price $4.44 · est. market cap ~$354M — last insider purchase, 2026-04-21 (estimated from the dated SEC Form 4 price × shares outstanding — not a live quote)
Grade
D42Clinical/early-stage biotech — oncology clinical, funded.
Strengths
- Liquidity — current ratio 2.0 (26th)
Risks
- Pre-revenue, deep losses — per metrics
- Pre-revenue/clinical-stage — history of losses & need for capital per risk factors
- Binary clinical & funding risk — per 10-K
Notable findings
- Exec changeRecent 8-K item 5.02 8-K ↗
- Net lossNet loss (net margin -819.6%)
- Cash burnNegative free cash flow (-56.4M)
- Fund exitedNotable fund(s) exited this quarter: VANGUARD GROUP INC
- Chronic dilutionShare count +18%/yr over 3y (dilution, book value/share -79%)
- Insider buyingInsider buying — 4 open-market buy(s) by 2 insider(s) (cluster of 2 insiders, ~$25M, last 6mo) Form 4 ↗
- New fund positionNotable fund(s) opened this quarter: CITADEL ADVISORS LLC
- Revenue declineRevenue -18.8% YoY
- Notable holderHeld by 5 notable fund(s): RENAISSANCE TECHNOLOGIES LLC, GOLDMAN SACHS GROUP INC, STATE STREET CORP +2 more (as of 2026-03-31)
Quarterly revenue
Last 4 quarters · from SEC filings.
Key metrics
Operating margin
-861.3%
Net margin
-819.6%
Return on equity
-145.0%
Return on assets
-70.4%
Revenue growth (QoQ)
-18.8%
Current ratio
2.0×
Free cash flow
-$56M
EBITDA
-$103M
Tangible book value
$69M
Cash & investments
$103M
Cash runway
7q
Stock comp / revenue
98.1%
Insider transactions · last 18 months
| Date | Insider | Type | Shares | Price |
|---|---|---|---|---|
| 2026-04-27 | RA CAPITAL MANAGEMENT, L.P. | Other | 1.4M | — |
| 2026-04-21 | Bonita David P | Buy | 1.7M | $4.44 |
| 2026-04-21 | Bonita David P | Buy | 1.1M | $4.44 |
| 2026-04-21 | ORBIMED ADVISORS LLC | Buy | 1.7M | $4.44 |
| 2026-04-21 | ORBIMED ADVISORS LLC | Buy | 1.1M | $4.44 |
| 2025-10-04 | Huang Jane | Option exercise | 9.4K | — |
| 2025-10-04 | Huang Jane | Tax withheld | 3.4K | $1.47 |
| 2025-07-04 | Huang Jane | Option exercise | 9.4K | — |
| 2025-07-04 | Huang Jane | Tax withheld | 3.4K | $0.79 |
| 2025-04-04 | Huang Jane | Option exercise | 9.4K | — |
| 2025-04-04 | Huang Jane | Tax withheld | 3.4K | $0.68 |
| 2025-03-25 | Combs Andrew | Buy | 100K | $0.69 |
| 2025-03-25 | Vaddi Krishna | Buy | 675K | $0.69 |
| 2025-03-21 | Vaddi Krishna | Buy | 15K | $0.73 |
| 2025-03-20 | Vaddi Krishna | Buy | 5.4K | $0.73 |
| 2025-03-17 | Vaddi Krishna | Buy | 9.1K | $0.75 |
| 2025-03-14 | Vaddi Krishna | Buy | 30K | $0.75 |
| 2025-03-13 | Vaddi Krishna | Buy | 50K | $0.72 |
| 2025-03-12 | Vaddi Krishna | Buy | 48K | $0.71 |
| 2025-01-04 | Huang Jane | Option exercise | 9.4K | — |
| 2025-01-04 | Huang Jane | Tax withheld | 3.9K | $1.39 |
| 2024-12-31 | Vaddi Krishna | Buy | 5.0K | $1.21 |
| 2024-12-30 | Vaddi Krishna | Buy | 10K | $1.20 |
All non-derivative Form 4 activity (SEC), newest first.
Notable events (8-K)
| Date | Items | |
|---|---|---|
| 2026-06-10 | Shareholder vote | filing ↗ |
| 2026-05-12 | ResultsReg FDExhibits | filing ↗ |
| 2026-04-21 | Material agreementOtherExhibits | filing ↗ |
| 2026-04-20 | Reg FDOtherExhibits | filing ↗ |
| 2026-04-15 | Exec/director changeExhibits | filing ↗ |
| 2026-03-12 | OtherExhibits | filing ↗ |
| 2026-03-10 | ResultsReg FDExhibits | filing ↗ |
| 2026-02-03 | Reg FDExhibits | filing ↗ |
Recent filings
| Form | Filed | Period | Accession |
|---|---|---|---|
| 8-K | 2026-06-10 | 2026-06-09 | 0001193125-26-265835 ↗ |
| 8-K | 2026-05-12 | 2026-05-12 | 0001193125-26-218162 ↗ |
| 10-Q | 2026-05-12 | 2026-03-31 | 0001193125-26-218173 ↗ |
| 8-K | 2026-04-21 | 2026-04-20 | 0001193125-26-164510 ↗ |
| 8-K | 2026-04-20 | 2026-04-20 | 0001193125-26-162620 ↗ |
| 8-K | 2026-04-15 | 2026-04-15 | 0001193125-26-155978 ↗ |
| 8-K | 2026-03-12 | 2026-03-12 | 0001193125-26-104204 ↗ |
| 10-K | 2026-03-10 | 2025-12-31 | 0001193125-26-099428 ↗ |
| 8-K | 2026-03-10 | 2026-03-10 | 0001193125-26-099424 ↗ |
| 8-K | 2026-02-03 | 2026-01-29 | 0001193125-26-034564 ↗ |
| 8-K | 2026-01-09 | 2026-01-09 | 0001193125-26-008280 ↗ |
| 10-Q | 2025-11-12 | 2025-09-30 | 0001193125-25-275887 ↗ |