Praxis Precision Medicines, Inc.
PRAX · Pharmaceutical Preparations · 27.9M shares · -7%/yr ↓ buyback · EDGAR filings ↗
Reference price $190.86 · est. market cap ~$5.3B — last insider sale, 2025-11-20 (estimated from the dated SEC Form 4 price × shares outstanding — not a live quote)
Grade
D46Clinical/early-stage biotech — CNS/epilepsy clinical, heavy burn ($249M), funded.
Strengths
- Liquidity — current ratio 10.2 (79th)
Risks
- Pre-revenue, deep losses — per metrics
- Pre-revenue/clinical-stage — history of losses & need for capital per risk factors
- Binary clinical & funding risk — per 10-K
Notable findings
- Fund exitedNotable fund(s) exited this quarter: VANGUARD GROUP INC, RENAISSANCE TECHNOLOGIES LLC
- Cash burnNegative free cash flow (-249.1M)
- Exec changeRecent 8-K item 5.02 8-K ↗
- Buying back stockNet buyback — share count -7%/yr over 4y
- Strong balance sheetStrong balance sheet — $1.3B cash & investments, ~20 quarters of runway
- Revenue declineRevenue -100.0% YoY
- Notable holderHeld by 4 notable fund(s): FMR LLC, STATE STREET CORP, GOLDMAN SACHS GROUP INC +1 more (as of 2026-03-31)
Quarterly revenue
Last 4 quarters · from SEC filings.
Key metrics
Return on equity
-34.5%
Return on assets
-32.3%
Revenue growth (QoQ)
-100.0%
Current ratio
10.2×
Free cash flow
-$249M
Tangible book value
$878M
Cash & investments
$1.3B
Cash runway
20q
Insider transactions · last 18 months
| Date | Insider | Type | Shares | Price |
|---|---|---|---|---|
| 2026-06-10 | Chodakewitz Jeffrey | Grant | 1.4K | — |
| 2026-06-10 | Arbuckle Stuart A | Grant | 1.4K | — |
| 2026-06-10 | YOUNG WILLIAM D | Grant | 1.4K | — |
| 2026-06-10 | DeSimone Jill | Grant | 1.4K | — |
| 2026-06-10 | Cudkowicz Merit Ester | Grant | 1.4K | — |
| 2026-06-10 | MITCHELL DEAN J | Grant | 1.4K | — |
| 2026-06-10 | KINDLER JEFFREY B | Grant | 1.4K | — |
| 2026-06-10 | Norden Gregory | Grant | 1.4K | — |
| 2026-05-14 | Nemiroff Alex | Grant | 78 | $167.94 |
| 2026-05-14 | Mastrocola Lauren | Grant | 127 | $167.94 |
| 2026-05-14 | Sniecinski Megan | Grant | 89 | $167.94 |
| 2026-05-14 | Souza Marcio | Grant | 126 | $167.94 |
| 2026-05-14 | Kelly Timothy Edwin | Grant | 121 | $167.94 |
| 2026-02-06 | Arbuckle Stuart A | Grant | 688 | — |
| 2026-02-06 | Arbuckle Stuart A | Grant | 478 | — |
| 2026-02-06 | KINDLER JEFFREY B | Grant | 688 | — |
| 2026-02-06 | KINDLER JEFFREY B | Grant | 478 | — |
| 2026-01-12 | Nemiroff Alex | Tax withheld | 768 | $275.74 |
| 2026-01-12 | Kelly Timothy Edwin | Tax withheld | 943 | $275.74 |
| 2026-01-12 | Mastrocola Lauren | Tax withheld | 344 | $275.74 |
| 2026-01-12 | Sniecinski Megan | Tax withheld | 885 | $275.74 |
| 2026-01-10 | Nemiroff Alex | Tax withheld | 917 | $288.45 |
| 2026-01-10 | Sniecinski Megan | Tax withheld | 1.1K | $288.45 |
| 2026-01-10 | Kelly Timothy Edwin | Tax withheld | 1.3K | $288.45 |
| 2026-01-10 | Mastrocola Lauren | Tax withheld | 367 | $288.45 |
| 2026-01-10 | Souza Marcio | Tax withheld | 4.3K | $288.45 |
| 2026-01-08 | Mastrocola Lauren | Grant | 3.8K | — |
| 2026-01-08 | Sniecinski Megan | Grant | 9.6K | — |
| 2026-01-08 | Nemiroff Alex | Grant | 6.9K | — |
| 2026-01-08 | Kelly Timothy Edwin | Grant | 8.8K | — |
| 2026-01-08 | Souza Marcio | Grant | 28K | — |
| 2026-01-07 | Kelly Timothy Edwin | Tax withheld | 139 | $292.63 |
| 2026-01-07 | Nemiroff Alex | Tax withheld | 89 | $292.63 |
| 2026-01-07 | Mastrocola Lauren | Tax withheld | 35 | $292.63 |
| 2026-01-07 | Souza Marcio | Tax withheld | 405 | $292.63 |
| 2025-12-30 | Souza Marcio | Gift | 400 | — |
| 2025-11-20 | Mastrocola Lauren | Option exercise | 5.2K | $56.94 |
| 2025-11-20 | Nemiroff Alex | Option exercise | 1.7K | $83.85 |
| 2025-11-20 | Nemiroff Alex | Option exercise | 6.2K | $133.65 |
| 2025-11-20 | Nemiroff Alex | Option exercise | 2.4K | $44.40 |
| 2025-11-20 | Nemiroff Alex | Option exercise | 5.7K | $44.40 |
| 2025-11-20 | Nemiroff Alex | Option exercise | 9.1K | $56.94 |
| 2025-11-20 | Nemiroff Alex | Sell | 1.7K | $190.86 |
| 2025-11-20 | Nemiroff Alex | Sell | 13K | $192.53 |
| 2025-11-20 | Nemiroff Alex | Sell | 977 | $193.23 |
| 2025-11-20 | Nemiroff Alex | Sell | 9.1K | $194.30 |
| 2025-11-20 | Mastrocola Lauren | Option exercise | 1.0K | $49.50 |
| 2025-11-20 | Mastrocola Lauren | Option exercise | 508 | $83.85 |
| 2025-11-20 | Mastrocola Lauren | Option exercise | 1.6K | $133.65 |
| 2025-11-20 | Mastrocola Lauren | Option exercise | 2.7K | $43.37 |
| 2025-11-20 | Mastrocola Lauren | Option exercise | 207 | $44.40 |
| 2025-11-20 | Mastrocola Lauren | Option exercise | 2.4K | $44.40 |
| 2025-11-20 | Mastrocola Lauren | Sell | 11K | $191.96 |
| 2025-11-20 | Mastrocola Lauren | Sell | 2.1K | $192.71 |
| 2025-11-14 | Kelly Timothy Edwin | Grant | 384 | $31.62 |
| 2025-10-16 | Adage Capital Management, L.P. | Sell | 13K | $90.00 |
| 2025-10-16 | Adage Capital Management, L.P. | Sell | 1.4K | $92.03 |
| 2025-10-16 | Adage Capital Management, L.P. | Sell | 559 | $100.11 |
| 2025-10-16 | Adage Capital Management, L.P. | Sell | 27K | $101.00 |
| 2025-10-16 | Adage Capital Management, L.P. | Sell | 250K | $104.31 |
| 2025-10-16 | Adage Capital Management, L.P. | Sell | 1.7K | $130.10 |
| 2025-10-16 | Adage Capital Management, L.P. | Sell | 487 | $131.64 |
| 2025-10-16 | Adage Capital Management, L.P. | Sell | 308 | $132.19 |
| 2025-10-16 | Adage Capital Management, L.P. | Sell | 447 | $91.04 |
| 2025-10-16 | Adage Capital Management, L.P. | Sell | 19K | $140.00 |
| 2025-09-24 | MITCHELL DEAN J | Option exercise | 1.8K | $44.04 |
| 2025-09-24 | MITCHELL DEAN J | Option exercise | 1.9K | $14.36 |
| 2025-09-24 | MITCHELL DEAN J | Option exercise | 8.6K | $44.25 |
| 2025-05-14 | Souza Marcio | Grant | 348 | $31.54 |
| 2025-05-14 | Kelly Timothy Edwin | Grant | 249 | $31.54 |
| 2025-02-12 | Nemiroff Alex | Tax withheld | 51 | $85.40 |
| 2025-02-12 | Mastrocola Lauren | Tax withheld | 40 | $85.40 |
| 2025-02-12 | Souza Marcio | Tax withheld | 401 | $85.40 |
| 2025-01-12 | Nemiroff Alex | Tax withheld | 579 | $63.15 |
| 2025-01-12 | Mastrocola Lauren | Tax withheld | 390 | $63.15 |
| 2025-01-12 | Kelly Timothy Edwin | Tax withheld | 676 | $63.15 |
| 2025-01-10 | Kelly Timothy Edwin | Grant | 12K | — |
| 2025-01-10 | Mastrocola Lauren | Grant | 5.0K | — |
| 2025-01-10 | Nemiroff Alex | Grant | 11K | — |
| 2025-01-10 | Souza Marcio | Grant | 38K | — |
| 2025-01-07 | Nemiroff Alex | Tax withheld | 89 | $77.52 |
| 2025-01-07 | Souza Marcio | Tax withheld | 434 | $77.52 |
| 2025-01-07 | Mastrocola Lauren | Tax withheld | 35 | $77.52 |
| 2025-01-07 | Kelly Timothy Edwin | Tax withheld | 139 | $77.52 |
All non-derivative Form 4 activity (SEC), newest first.
Notable events (8-K)
Recent filings
| Form | Filed | Period | Accession |
|---|---|---|---|
| 8-K | 2026-06-22 | 2026-06-22 | 0001689548-26-000066 ↗ |
| 8-K | 2026-06-12 | 2026-06-10 | 0001689548-26-000056 ↗ |
| 8-K | 2026-06-01 | 2026-06-01 | 0001689548-26-000053 ↗ |
| 8-K | 2026-05-07 | 2026-05-07 | 0001689548-26-000049 ↗ |
| 10-Q | 2026-05-07 | 2026-03-31 | 0001689548-26-000047 ↗ |
| 8-K | 2026-04-14 | 2026-04-14 | 0001689548-26-000033 ↗ |
| 8-K | 2026-04-06 | 2026-04-06 | 0001689548-26-000031 ↗ |
| 10-K | 2026-02-19 | 2025-12-31 | 0001689548-26-000029 ↗ |
| 8-K | 2026-02-19 | 2026-02-19 | 0001689548-26-000028 ↗ |
| 8-K/A | 2026-02-10 | 2026-02-06 | 0001689548-26-000016 ↗ |
| 8-K | 2026-01-08 | 2026-01-08 | 0001689548-26-000005 ↗ |
| 8-K | 2026-01-07 | 2026-01-06 | 0001104659-26-001825 ↗ |