‹ Screener

Krystal Biotech, Inc.

KRYS · Biological Products, (No Diagnostic Substances) · 29.5M shares · +10%/yr ↑ shares · EDGAR filings ↗

Reference price $300.75 · est. market cap ~$8.9B — last insider sale, 2026-06-04 (estimated from the dated SEC Form 4 price × shares outstanding — not a live quote)

Grade

A87

Profitable, cash-generative gene-therapy franchise with an approved, globally launching product and top-decile margins and returns.

Strengths

Risks

Notable findings

Quarterly revenue

2025-06-30 · $96M2025-09-30 · $98M2025-12-31 · $107M2026-03-31 · $116M

Last 4 quarters · from SEC filings.

Key metrics

Operating margin
41.5%
Net margin
52.6%
Return on equity
16.8%
Return on assets
15.4%
Revenue growth (QoQ)
8.6%
Net-income growth
129.7%
Current ratio
10.0×
Free cash flow
$189M
Tangible book value
$1.2B
Cash & investments
$956M
Stock comp / revenue
14.0%

Insider transactions · last 18 months

DateInsiderTypeSharesPrice
2026-06-04Krishnan SumaSell3.8K$308.89
2026-06-04Krishnan SumaSell480$305.87
2026-06-04Krishnan SumaSell2.8K$309.95
2026-06-04Krishnan SumaSell2.0K$310.94
2026-06-04Krishnan SumaSell240$311.65
2026-06-04Krishnan Krish SSell320$300.75
2026-06-04Krishnan Krish SSell640$302.24
2026-06-04Krishnan SumaSell320$300.75
2026-06-04Krishnan Krish SSell176$303.17
2026-06-04Krishnan Krish SSell544$304.81
2026-06-04Krishnan Krish SSell589$306.33
2026-06-04Krishnan Krish SSell11K$307.68
2026-06-04Krishnan SumaSell247$303.17
2026-06-04Krishnan Krish SSell4.8K$308.47
2026-06-04Krishnan Krish SSell2.8K$309.49
2026-06-04Krishnan SumaSell1.3K$307.09
2026-06-04Krishnan Krish SSell2.7K$310.43
2026-06-04Krishnan Krish SSell964$311.36
2026-06-04Krishnan Krish SSell40$312.23
2026-06-04Krishnan SumaSell593$302.25
2026-06-04Krishnan SumaSell13K$307.81
2026-06-04Krishnan SumaSell400$304.89
2026-05-26Thomas John CharlesSell642$302.03
2026-03-04Krishnan Krish SSell2.4K$262.44
2026-03-04Krishnan SumaSell407$257.32
2026-03-04Krishnan SumaSell589$258.54
2026-03-04Krishnan SumaSell668$259.61
2026-03-04Krishnan SumaSell3.7K$260.37
2026-03-04Krishnan SumaSell2.9K$261.41
2026-03-04Krishnan SumaSell1.9K$262.35
2026-03-04Krishnan SumaSell2.2K$263.58
2026-03-04Krishnan SumaSell4.9K$264.64
2026-03-04Krishnan SumaSell6.0K$265.16
2026-03-04Krishnan SumaSell1.7K$266.42
2026-03-04Krishnan Krish SSell483$257.31
2026-03-04Krishnan Krish SSell470$258.38
2026-03-04Krishnan Krish SSell1.4K$259.87
2026-03-04Krishnan Krish SSell3.1K$260.49
2026-03-04Krishnan Krish SSell3.0K$261.41
2026-03-04Krishnan Krish SSell2.0K$263.70
2026-03-04Krishnan Krish SSell8.8K$264.85
2026-03-04Krishnan Krish SSell2.4K$265.59
2026-03-04Krishnan Krish SSell920$266.56
2026-03-02ROMANO KATHRYNSell750$267.60
2026-02-27Krishnan Krish STax withheld2.6K$275.64
2026-02-27ROMANO KATHRYNOption exercise7.5K
2026-02-27ROMANO KATHRYNTax withheld3.3K$275.64
2026-02-27ROMANO KATHRYNOption exercise550
2026-02-27ROMANO KATHRYNTax withheld240$275.64
2026-02-27JANNEY DANIELSell9.4K$275.45
2026-02-27JANNEY DANIELSell2.4K$276.17
2026-02-27Krishnan SumaOption exercise22K
2026-02-27Krishnan SumaTax withheld10K$275.64
2026-02-27Krishnan SumaOption exercise4.0K
2026-02-27Krishnan SumaTax withheld1.8K$275.64
2026-02-27Krishnan SumaOption exercise8.8K
2026-02-27Krishnan SumaTax withheld4.0K$275.64
2026-02-27Krishnan SumaOption exercise26K
2026-02-27Krishnan SumaTax withheld12K$275.64
2026-02-27Krishnan SumaOption exercise5.7K
2026-02-27Krishnan SumaTax withheld2.6K$275.64
2026-02-27Krishnan Krish SOption exercise8.8K
2026-02-27Krishnan Krish STax withheld4.0K$275.64
2026-02-27Krishnan Krish SOption exercise26K
2026-02-27Krishnan Krish STax withheld12K$275.64
2026-02-27Krishnan Krish SOption exercise5.7K
2026-02-27Krishnan Krish SOption exercise22K
2026-02-27Krishnan Krish STax withheld10K$275.64
2026-02-27Krishnan Krish SOption exercise4.0K
2026-02-27Krishnan Krish STax withheld1.8K$275.64
2026-02-26JANNEY DANIELSell5.1K$275.28
2026-02-26JANNEY DANIELSell2.6K$276.32
2026-02-25JANNEY DANIELSell700$275.00
2026-02-24JANNEY DANIELSell3.6K$265.08
2026-02-24JANNEY DANIELSell9.0K$266.18
2026-02-24JANNEY DANIELSell12K$266.97
2026-02-24JANNEY DANIELSell6.7K$268.04
2026-02-24JANNEY DANIELSell4.0K$268.97
2026-02-24JANNEY DANIELSell370$269.83
2026-02-24JANNEY DANIELSell373$271.09
2026-02-24JANNEY DANIELSell62$263.05
2026-02-24JANNEY DANIELSell900$264.60
2026-02-24JANNEY DANIELSell1.6K$265.54
2026-02-24JANNEY DANIELSell4.3K$266.62
2026-02-24JANNEY DANIELSell1.9K$267.37
2026-02-24JANNEY DANIELSell1.7K$268.67
2026-02-24JANNEY DANIELSell930$269.50
2026-02-24JANNEY DANIELSell2.4K$274.90
2026-02-24JANNEY DANIELOption exercise38K$2.46
2026-02-24JANNEY DANIELSell569$262.91
2026-02-24JANNEY DANIELSell1.7K$264.12
2026-02-19ROSSI DINO AOption exercise19K$8.79
2026-02-19ROSSI DINO ASell8.1K$260.49
2026-02-19ROSSI DINO ASell11K$262.10
2026-02-09ROMANO KATHRYNOption exercise12K$63.55
2026-02-09ROMANO KATHRYNSell2.0K$270.56
2026-02-09ROMANO KATHRYNSell5.7K$271.66
2026-02-09ROMANO KATHRYNSell2.8K$272.51
2026-02-09ROMANO KATHRYNSell928$273.71
2026-02-09ROMANO KATHRYNSell552$274.64
2026-02-09ROMANO KATHRYNSell400$275.68
2026-02-09ROMANO KATHRYNSell96$277.88
2026-02-09ROMANO KATHRYNGift750
2025-12-05Krishnan Krish SGift5.0K
2025-12-05Krishnan SumaGift5.0K
2025-12-04Krishnan Krish SSell10K$221.82
2025-12-04Krishnan SumaSell700$214.25
2025-12-04Krishnan SumaSell600$215.49
2025-12-04Krishnan SumaSell1.4K$216.97
2025-12-04Krishnan SumaSell3.6K$218.83
2025-12-04Krishnan SumaSell5.4K$219.68
2025-12-04Krishnan SumaSell2.6K$220.52
2025-12-04Krishnan SumaSell10K$221.82
2025-12-04Krishnan SumaSell200$222.38
2025-12-04Krishnan SumaSell956$214.28
2025-12-04Krishnan SumaSell344$215.48
2025-12-04Krishnan SumaSell1.6K$217.04
2025-12-04Krishnan SumaSell2.6K$218.72
2025-12-04Krishnan SumaSell5.7K$219.53
2025-12-04Krishnan SumaSell2.6K$220.34
2025-12-04Krishnan SumaSell11K$221.78
2025-12-04Krishnan SumaSell700$222.20
2025-12-04Krishnan Krish SSell956$214.28
2025-12-04Krishnan Krish SSell344$215.48
2025-12-04Krishnan Krish SSell1.6K$217.04
2025-12-04Krishnan Krish SSell2.6K$218.72
2025-12-04Krishnan Krish SSell5.7K$219.55
2025-12-04Krishnan Krish SSell2.6K$220.34
2025-12-04Krishnan Krish SSell11K$221.78
2025-12-04Krishnan Krish SSell700$222.20
2025-12-04Krishnan Krish SSell700$214.25
2025-12-04Krishnan Krish SSell600$215.49
2025-12-04Krishnan Krish SSell1.4K$216.97
2025-12-04Krishnan Krish SSell3.6K$218.83
2025-12-04Krishnan Krish SSell5.4K$219.68
2025-12-04Krishnan Krish SSell2.6K$220.52
2025-12-04Krishnan Krish SSell200$222.38
2025-07-16Krishnan SumaSell1.4K$150.00
2025-07-16Krishnan SumaSell1.5K$150.00
2025-07-16Krishnan Krish SSell1.5K$150.00
2025-07-16Krishnan Krish SSell1.4K$150.00
2025-07-15Krishnan SumaSell2.2K$150.68
2025-07-15Krishnan SumaSell900$151.79
2025-07-15Krishnan SumaSell800$151.79
2025-07-15Krishnan Krish SSell2.2K$150.68
2025-07-15Krishnan Krish SSell900$151.79
2025-07-15Krishnan SumaSell2.2K$150.68
2025-07-15Krishnan Krish SSell2.2K$150.68
2025-07-15Krishnan Krish SSell800$151.79
2025-07-14Krishnan SumaSell13K$150.29
2025-07-14Krishnan SumaSell100$151.00
2025-07-14Krishnan SumaSell13K$150.30
2025-07-14Krishnan Krish SSell13K$150.30
2025-07-14Krishnan Krish SSell13K$150.29
2025-07-14Krishnan Krish SSell100$151.00
2025-07-10Krishnan Krish SSell300$151.39
2025-07-10Krishnan SumaSell6.5K$150.23
2025-07-10Krishnan Krish SSell6.5K$150.23
2025-07-10Krishnan Krish SSell300$151.39
2025-07-10Krishnan SumaSell6.6K$150.22
2025-07-10Krishnan SumaSell300$151.39
2025-07-10Krishnan SumaSell300$151.39
2025-07-10Krishnan Krish SSell6.6K$150.22
2025-07-09Krishnan Krish SSell200$150.07
2025-07-09Krishnan SumaSell200$150.07
2025-07-09Krishnan SumaSell200$150.14
2025-07-09Krishnan Krish SSell200$150.14
2025-03-13Krishnan SumaSell1.6K$175.97
2025-03-13Krishnan SumaSell4.6K$176.88
2025-03-13Krishnan SumaSell11K$177.66
2025-03-13Krishnan SumaSell6.5K$178.76
2025-03-13Krishnan SumaSell1.3K$179.55
2025-03-13Krishnan SumaSell1.1K$175.83
2025-03-13Krishnan SumaSell4.9K$176.80
2025-03-13Krishnan SumaSell11K$177.62
2025-03-13Krishnan SumaSell6.8K$178.77
2025-03-13Krishnan SumaSell1.3K$179.57
2025-03-13Krishnan Krish SSell1.1K$175.83
2025-03-13Krishnan Krish SSell4.9K$176.80
2025-03-13Krishnan Krish SSell11K$177.62
2025-03-13Krishnan Krish SSell6.8K$178.77
2025-03-13Krishnan Krish SSell1.3K$179.57
2025-03-13Krishnan Krish SSell1.6K$175.97
2025-03-13Krishnan Krish SSell4.6K$176.88
2025-03-13Krishnan Krish SSell11K$177.66
2025-03-13Krishnan Krish SSell6.5K$178.76
2025-03-13Krishnan Krish SSell1.3K$179.55
2025-02-28Krishnan Krish STax withheld12K$179.25
2025-02-28Krishnan Krish STax withheld3.5K$179.25
2025-02-28Krishnan Krish SOption exercise22K
2025-02-28Krishnan Krish STax withheld10K$179.25
2025-02-28ROMANO KATHRYNOption exercise7.5K
2025-02-28ROMANO KATHRYNTax withheld3.5K$179.25
2025-02-28Krishnan Krish SOption exercise7.5K
2025-02-28Krishnan SumaOption exercise7.5K
2025-02-28Krishnan SumaTax withheld3.5K$179.25
2025-02-28Krishnan SumaOption exercise22K
2025-02-28Krishnan SumaTax withheld10K$179.25
2025-02-28Krishnan SumaOption exercise12K
2025-02-28Krishnan SumaTax withheld5.8K$179.25
2025-02-28Krishnan SumaOption exercise8.8K
2025-02-28Krishnan SumaTax withheld4.0K$179.25
2025-02-28Krishnan SumaOption exercise26K
2025-02-28Krishnan SumaTax withheld12K$179.25
2025-02-28ROMANO KATHRYNOption exercise5.0K
2025-02-28ROMANO KATHRYNTax withheld2.3K$179.25
2025-02-28Krishnan Krish SOption exercise12K
2025-02-28Krishnan Krish STax withheld5.8K$179.25
2025-02-28Krishnan Krish SOption exercise8.8K
2025-02-28Krishnan Krish STax withheld4.0K$179.25
2025-02-28Krishnan Krish SOption exercise26K
2025-02-27ROMANO KATHRYNSell750$175.22
2025-02-26Krishnan Krish STax withheld3.3K$176.39
2025-02-26Krishnan SumaTax withheld3.3K$176.39
2025-02-26Krishnan SumaTax withheld4.7K$176.39
2025-02-26Krishnan Krish STax withheld4.7K$176.39
2025-02-26ROMANO KATHRYNTax withheld2.3K$176.39

All non-derivative Form 4 activity (SEC), newest first.

Clinical trials

TrialTitlePhaseStatusPrimary completion
NCT04917887 ↗Long-Term Follow-up Protocol
Dystrophic Epidermolysis Bullosa, Recessive Dystrophic Epidermolysis Bullosa
Recruiting2028-05-25
NCT05970497 ↗A Study Assessing KB707 for the Treatment of Locally Advanced or Metastatic Solid Tumors
Cancer, Melanoma Stage III
PHASE1/PHASE2Recruiting2027-07-01
NCT06228326 ↗A Study Assessing KB707 for the Treatment of Advanced Solid Tumor Malignancies Affecting the Lungs
Lung Cancer, Non-small Cell, Lung Cancer Metastatic
PHASE1/PHASE2Recruiting2027-02-01
NCT07016750 ↗A Study Comparing KB803 and Matched Placebo in Patients With Dystrophic Epidermolysis Bullosa
Dystrophic Epidermolysis Bullosa, DEB - Dystrophic Epidermolysis Bullosa
PHASE3Recruiting2026-12-01
NCT06999733 ↗A Study Comparing KB801 Verse Placebo in Patients With Stage 2 or 3 Neurotrophic Keratitis
Neurotrophic Keratitis
PHASE1/PHASE2Recruiting2026-12-01
NCT05504837 ↗A Study Assessing KB407 for the Treatment of Cystic Fibrosis
Cystic Fibrosis
PHASE1Recruiting2026-12-01
NCT06049082 ↗A Study of KB408 for the Treatment of Alpha-1 Antitrypsin Deficiency
Alpha 1-Antitrypsin Deficiency
PHASE1Recruiting2025-12-01
NCT06563414 ↗A Natural History Study of Corneal Abrasions in Patients With Dystrophic Epidermolysis Bullosa (DEB)
Epidermolysis Bullosa Dystrophica, Epidermolysis Bullosa Dystrophica, Recessive
Recruiting2025-12-01
NCT06724900 ↗A Study Assessing KB304 for the Treatment of Wrinkles in Women
Wrinkles in Decolletage, Pigmentation
PHASE1/PHASE2Active Not Recruiting2025-07-01
NCT04540900 ↗A Phase I Study of KB301, a Replication-Incompetent, Non-Integrating Vector Expressing Human Type III Collagen (COL3) for the Treatment of Superficial Skin Depressions
Skin Roughness, Wrinkle
PHASE1Active Not Recruiting2024-10-16
NCT05095246 ↗A Study of Inhaled KB407 for the Treatment of Cystic Fibrosis
Cystic Fibrosis
PHASE1Withdrawn2024-07-01
NCT05735158 ↗Topical KB105 for the Treatment of TGM1-deficient Autosomal Recessive Congenital Ichthyosis (ARCI)
Autosomal Recessive Ichthyosis
PHASE2Unknown2024-03-01
NCT04917874 ↗A Long-term Treatment With B-VEC for Dystrophic Epidermolysis Bullosa
Dystrophic Epidermolysis Bullosa, DEB - Dystrophic Epidermolysis Bullosa
PHASE3Completed2023-07-31
NCT04047732 ↗Topical KB105 Gene Therapy for the Treatment of TGM1-deficient Autosomal Recessive Congenital Ichthyosis (ARCI)
TGM-1 Related Autosomal Recessive Congenital Ichthyosis
PHASE1/PHASE2Unknown2022-10-01
NCT04491604 ↗Ph 3 Efficacy and Safety of B-VEC for the Treatment of DEB
Dystrophic Epidermolysis Bullosa, Recessive Dystrophic Epidermolysis Bullosa
PHASE3Completed2021-10-29
NCT04214002 ↗The Natural History of Wounds in Patients With Dystrophic Epidermolysis Bullosa (DEB)
Dystrophic Epidermolysis Bullosa, DEB - Dystrophic Epidermolysis Bullosa
Withdrawn2020-02-24
NCT03536143 ↗A Phase I/II Study of KB103, a Topical HSV1-COL7, on DEB Patients
Dystrophic Epidermolysis Bullosa
PHASE1/PHASE2Completed2019-11-01

Source: ClinicalTrials.gov (U.S. NIH) · active studies first.

Notable events (8-K)

DateItems
2026-05-20Shareholder votefiling ↗
2026-05-04Exhibitsfiling ↗
2026-02-17Resultsfiling ↗
2026-01-12ResultsReg FDExhibitsfiling ↗
2026-01-08Reg FDExhibitsfiling ↗
2025-12-23Exec/director changeExhibitsfiling ↗
2025-11-03Resultsfiling ↗
2025-10-22Otherfiling ↗

Recent filings

FormFiledPeriodAccession
8-K2026-05-202026-05-150001711279-26-000047 ↗
8-K2026-05-042026-05-040001711279-26-000044 ↗
10-Q2026-05-042026-03-310001711279-26-000043 ↗
8-K2026-02-172026-02-170001711279-26-000018 ↗
10-K2026-02-172025-12-310001711279-26-000016 ↗
8-K2026-01-122026-01-110001711279-26-000008 ↗
8-K2026-01-082026-01-080001711279-26-000005 ↗
8-K2025-12-232025-12-230001711279-25-000092 ↗
10-Q2025-11-032025-09-300001711279-25-000087 ↗
8-K2025-11-032025-11-030001711279-25-000088 ↗
8-K2025-10-222025-10-220001711279-25-000082 ↗
8-K2025-08-042025-08-040001711279-25-000078 ↗