Maze Therapeutics, Inc.
MAZE · Biological Products, (No Diagnostic Substances) · 55.3M shares · EDGAR filings ↗
Reference price $26.05 · est. market cap ~$1.4B — last insider sale, 2026-06-23 (estimated from the dated SEC Form 4 price × shares outstanding — not a live quote)
Grade
D46Clinical/early-stage biotech — precision-medicine clinical, very cash-rich.
Strengths
- Liquidity — current ratio 15.5 (93rd)
Risks
- Pre-revenue, deep losses — per metrics
- Pre-revenue/clinical-stage — history of losses & need for capital per risk factors
- Binary clinical & funding risk — per 10-K
Notable findings
- Fund exitedNotable fund(s) exited this quarter: VANGUARD GROUP INC
- Cash burnNegative free cash flow (-112.7M)
- Exec changeRecent 8-K item 5.02 8-K ↗
- Strong balance sheetStrong balance sheet — $360M cash & investments, ~13 quarters of runway
- Notable holderHeld by 5 notable fund(s): FMR LLC, CITADEL ADVISORS LLC, STATE STREET CORP +2 more (as of 2026-03-31)
- AccumulatingInstitutional holders rose 11→12 QoQ (2025-12-31→2026-03-31)
- Insider sellingInsider selling — 49 open-market sale(s) by 5 insider(s) (cluster of 5 insiders, ~$11M, last 6mo) Form 4 ↗
Quarterly revenue
Last 3 quarters · from SEC filings.
Key metrics
Return on equity
-36.9%
Return on assets
-33.0%
Net-income growth
-351.0%
Current ratio
15.5×
Free cash flow
-$113M
Tangible book value
$355M
Cash & investments
$360M
Cash runway
13q
Insider transactions · last 18 months
| Date | Insider | Type | Shares | Price |
|---|---|---|---|---|
| 2026-06-23 | Coloma Jason V | Sell | 24K | $26.05 |
| 2026-06-22 | Coloma Jason V | Sell | 2.0K | $26.00 |
| 2026-06-22 | Coloma Jason V | Sell | 2.0K | $26.00 |
| 2026-06-01 | Coloma Jason V | Sell | 6.1K | $26.20 |
| 2026-06-01 | Bernstein Harold | Sell | 1.6K | $26.36 |
| 2026-06-01 | Coloma Jason V | Sell | 553 | $26.24 |
| 2026-06-01 | Bernstein Harold | Option exercise | 15K | $10.42 |
| 2026-06-01 | Bernstein Harold | Sell | 13K | $25.57 |
| 2026-05-29 | Dandekar Atul | Option exercise | 7.5K | $10.42 |
| 2026-05-29 | Dandekar Atul | Sell | 7.5K | $26.34 |
| 2026-05-26 | Coloma Jason V | Sell | 26K | $26.02 |
| 2026-05-22 | Coloma Jason V | Sell | 4.5K | $26.00 |
| 2026-05-22 | Coloma Jason V | Sell | 2.5K | $26.00 |
| 2026-05-15 | Coloma Jason V | Sell | 1.8K | $26.00 |
| 2026-05-15 | Coloma Jason V | Sell | 116 | $26.00 |
| 2026-05-14 | Bernstein Harold | Option exercise | 15K | $10.42 |
| 2026-05-14 | Bernstein Harold | Sell | 15K | $26.22 |
| 2026-05-04 | Dandekar Atul | Option exercise | 6.0K | $10.42 |
| 2026-05-04 | Dandekar Atul | Option exercise | 8.3K | $10.42 |
| 2026-05-04 | HOMCY CHARLES J | Gift | 7.4K | — |
| 2026-04-29 | Dandekar Atul | Sell | 7.5K | $25.37 |
| 2026-04-29 | Dandekar Atul | Option exercise | 7.5K | $10.42 |
| 2026-04-01 | Bachrodt Amy | Sell | 2.2K | $29.32 |
| 2026-04-01 | Bachrodt Amy | Option exercise | 2.5K | $10.42 |
| 2026-04-01 | Bachrodt Amy | Sell | 300 | $30.34 |
| 2026-04-01 | Bernstein Harold | Option exercise | 15K | $10.42 |
| 2026-04-01 | Bernstein Harold | Sell | 11K | $29.24 |
| 2026-04-01 | Bernstein Harold | Sell | 3.3K | $30.06 |
| 2026-04-01 | Bernstein Harold | Sell | 300 | $31.07 |
| 2026-03-30 | Dandekar Atul | Option exercise | 7.5K | $10.42 |
| 2026-03-30 | Dandekar Atul | Sell | 6.7K | $29.26 |
| 2026-03-30 | Dandekar Atul | Sell | 790 | $30.02 |
| 2026-03-20 | Bernstein Harold | Option exercise | 15K | $10.42 |
| 2026-03-20 | Bernstein Harold | Sell | 6.2K | $48.20 |
| 2026-03-20 | Bernstein Harold | Sell | 3.8K | $49.32 |
| 2026-03-20 | Bernstein Harold | Sell | 5.0K | $50.02 |
| 2026-03-10 | Bernstein Harold | Option exercise | 30K | $10.42 |
| 2026-03-10 | Bernstein Harold | Sell | 30K | $50.45 |
| 2026-03-10 | Bernstein Harold | Sell | 348 | $51.02 |
| 2026-03-02 | Bachrodt Amy | Option exercise | 5.0K | $10.42 |
| 2026-03-02 | Bachrodt Amy | Sell | 1.3K | $44.44 |
| 2026-03-02 | Bachrodt Amy | Sell | 3.7K | $45.47 |
| 2026-02-27 | Dandekar Atul | Option exercise | 7.5K | $10.42 |
| 2026-02-27 | Dandekar Atul | Sell | 3.7K | $45.13 |
| 2026-02-27 | Dandekar Atul | Sell | 3.8K | $45.72 |
| 2026-02-02 | Bernstein Harold | Sell | 600 | $44.20 |
| 2026-02-02 | Bachrodt Amy | Option exercise | 4.8K | $10.42 |
| 2026-02-02 | Bachrodt Amy | Option exercise | 156 | $10.42 |
| 2026-02-02 | Bachrodt Amy | Sell | 200 | $44.15 |
| 2026-02-02 | Bachrodt Amy | Sell | 4.1K | $46.03 |
| 2026-02-02 | Bachrodt Amy | Sell | 736 | $46.63 |
| 2026-02-02 | Bernstein Harold | Option exercise | 15K | $10.42 |
| 2026-02-02 | Bernstein Harold | Sell | 8.4K | $45.89 |
| 2026-02-02 | Bernstein Harold | Sell | 5.9K | $46.37 |
| 2026-02-02 | Bernstein Harold | Sell | 100 | $47.23 |
| 2026-01-29 | Dandekar Atul | Sell | 1.2K | $43.18 |
| 2026-01-29 | Dandekar Atul | Option exercise | 7.5K | $10.42 |
| 2026-01-29 | Dandekar Atul | Sell | 2.8K | $45.01 |
| 2026-01-29 | Dandekar Atul | Sell | 3.5K | $44.04 |
| 2026-01-22 | Bachrodt Amy | Option exercise | 2.5K | $10.42 |
| 2026-01-22 | Bachrodt Amy | Option exercise | 2.5K | $10.42 |
| 2026-01-22 | Bachrodt Amy | Sell | 5.0K | $45.52 |
| 2026-01-07 | Sohn Catherine A. | Option exercise | 3.3K | $10.42 |
| 2026-01-07 | Bernstein Harold | Option exercise | 25K | $10.42 |
| 2026-01-07 | Bernstein Harold | Sell | 25K | $40.20 |
| 2026-01-07 | Sohn Catherine A. | Option exercise | 21K | $10.42 |
| 2026-01-07 | Sohn Catherine A. | Option exercise | 2.9K | $10.42 |
| 2026-01-07 | Sohn Catherine A. | Sell | 27K | $39.11 |
| 2026-01-06 | Sohn Catherine A. | Option exercise | 2.5K | $10.42 |
| 2026-01-06 | Sohn Catherine A. | Sell | 2.5K | $38.62 |
| 2026-01-05 | Bernstein Harold | Sell | 412 | $40.00 |
| 2026-01-05 | Bernstein Harold | Option exercise | 412 | $10.42 |
| 2026-01-02 | Bachrodt Amy | Option exercise | 4.8K | $10.42 |
| 2026-01-02 | Bachrodt Amy | Sell | 2.4K | $38.70 |
| 2026-01-02 | Bachrodt Amy | Sell | 2.6K | $39.57 |
| 2026-01-02 | Bernstein Harold | Option exercise | 4.4K | $10.42 |
| 2026-01-02 | Bernstein Harold | Sell | 4.4K | $40.43 |
| 2026-01-02 | Bachrodt Amy | Option exercise | 204 | $10.42 |
| 2025-12-30 | Dandekar Atul | Option exercise | 100 | $10.42 |
| 2025-12-30 | Bachrodt Amy | Option exercise | 2.4K | $10.42 |
| 2025-12-30 | Bachrodt Amy | Sell | 5.0K | $40.08 |
| 2025-12-30 | Dandekar Atul | Sell | 100 | $40.36 |
| 2025-12-30 | Bachrodt Amy | Option exercise | 2.6K | $10.42 |
| 2025-12-29 | Bernstein Harold | Option exercise | 45K | $10.42 |
| 2025-12-29 | Bachrodt Amy | Option exercise | 124 | $10.42 |
| 2025-12-29 | Bachrodt Amy | Option exercise | 9.9K | $10.42 |
| 2025-12-29 | Bachrodt Amy | Sell | 9.4K | $40.54 |
| 2025-12-29 | Bachrodt Amy | Sell | 600 | $41.16 |
| 2025-12-29 | Bernstein Harold | Sell | 28K | $40.34 |
| 2025-12-29 | Bernstein Harold | Sell | 17K | $40.93 |
| 2025-12-29 | Dandekar Atul | Option exercise | 72K | $10.42 |
| 2025-12-29 | Dandekar Atul | Sell | 66K | $40.51 |
| 2025-12-29 | Dandekar Atul | Sell | 6.0K | $41.13 |
| 2025-11-19 | HOMCY CHARLES J | Other | 1.5K | — |
| 2025-11-04 | Third Rock Ventures IV, L.P. | Other | 1.6M | — |
| 2025-10-23 | HOMCY CHARLES J | Gift | 28K | — |
| 2025-09-15 | SCHELLER RICHARD H | Sell | 21K | $22.37 |
| 2025-02-03 | Lim Jonathan E | Conversion | 38K | — |
| 2025-02-03 | Lim Jonathan E | Conversion | 270K | — |
| 2025-02-03 | HOMCY CHARLES J | Conversion | 8.8K | — |
| 2025-02-03 | HOMCY CHARLES J | Conversion | 21K | — |
| 2025-02-03 | Third Rock Ventures IV, L.P. | Conversion | 951K | — |
| 2025-02-03 | HOMCY CHARLES J | Conversion | 7.4K | — |
| 2025-02-03 | Third Rock Ventures IV, L.P. | Conversion | 5.8M | — |
All non-derivative Form 4 activity (SEC), newest first.
Notable events (8-K)
| Date | Items | |
|---|---|---|
| 2026-06-10 | Shareholder vote | filing ↗ |
| 2026-05-22 | Exec/director change | filing ↗ |
| 2026-05-12 | ResultsExhibits | filing ↗ |
| 2026-04-22 | OtherExhibits | filing ↗ |
| 2026-03-25 | ResultsExec/director changeReg FDExhibits | filing ↗ |
| 2026-02-04 | Material agreement1.02Debt obligation | filing ↗ |
| 2025-11-06 | ResultsExhibits | filing ↗ |
| 2025-10-06 | Exec/director change | filing ↗ |
Recent filings
| Form | Filed | Period | Accession |
|---|---|---|---|
| 8-K | 2026-06-10 | 2026-06-08 | 0001193125-26-265858 ↗ |
| 8-K | 2026-05-22 | 2026-05-18 | 0001193125-26-237199 ↗ |
| 8-K | 2026-05-12 | 2026-05-12 | 0001193125-26-219398 ↗ |
| 10-Q | 2026-05-12 | 2026-03-31 | 0001193125-26-219430 ↗ |
| 8-K | 2026-04-22 | 2026-04-21 | 0001193125-26-170701 ↗ |
| 10-K | 2026-03-25 | 2025-12-31 | 0001193125-26-122778 ↗ |
| 8-K | 2026-03-25 | 2026-03-24 | 0001193125-26-122774 ↗ |
| 8-K | 2026-02-04 | 2026-02-02 | 0001193125-26-037747 ↗ |
| 8-K | 2025-11-06 | 2025-11-06 | 0001193125-25-269624 ↗ |
| 10-Q | 2025-11-06 | 2025-09-30 | 0001193125-25-269689 ↗ |
| 8-K | 2025-10-06 | 2025-10-06 | 0001193125-25-230926 ↗ |
| 8-K | 2025-09-11 | 2025-09-10 | 0001193125-25-200760 ↗ |