Nuvalent, Inc.

NUVL · Pharmaceutical Preparations · 58.2M shares · +112%/yr ↑ dilution · EDGAR filings ↗

Reference price $122.81 · est. market cap ~$7.2B — last insider sale, 2026-06-09 (estimated from the dated SEC Form 4 price × shares outstanding — not a live quote)

Grade

D46

Clinical/early-stage biotech — oncology clinical, very cash-rich.

Strengths

Liquidity — current ratio 15.3 (91st)

Risks

Pre-revenue, deep losses — per metrics
Pre-revenue/clinical-stage — history of losses & need for capital per risk factors
Binary clinical & funding risk — per 10-K

Notable findings

Fund exitedNotable fund(s) exited this quarter: VANGUARD GROUP INC
Chronic dilutionShare count +112%/yr over 4y (dilution, book value/share -78%)
Strong balance sheetStrong balance sheet — $1.4B cash & investments
Notable holderHeld by 6 notable fund(s): FMR LLC, STATE STREET CORP, GOLDMAN SACHS GROUP INC +3 more (as of 2026-03-31)
New fund positionNotable fund(s) opened this quarter: RENAISSANCE TECHNOLOGIES LLC
Insider sellingInsider selling — 118 open-market sale(s) by 6 insider(s) (cluster of 6 insiders, ~$38M, last 6mo) Form 4 ↗

Key metrics

Return on equity

-34.1%

Return on assets

-30.1%

Current ratio

15.3×

Tangible book value

$1.2B

Cash & investments

$1.4B

Insider transactions · last 18 months

Date	Insider	Type	Shares	Price
2026-06-16	Bogle Grant C.	Grant	3.4K	—
2026-06-16	Srivastava Sapna	Grant	3.4K	—
2026-06-16	Meyers Michael L.	Grant	3.4K	—
2026-06-16	Squarer Ron	Grant	3.4K	—
2026-06-16	Protopapas Anna	Grant	3.4K	—
2026-06-16	Flynn James E	Grant	3.4K	—
2026-06-16	Wheeler Cameron	Grant	3.4K	—
2026-06-16	Oliger Christy J.	Grant	3.4K	—
2026-06-09	Noci Darlene	Option exercise	685	$6.89
2026-06-09	Noci Darlene	Option exercise	9.3K	$18.93
2026-06-09	Noci Darlene	Sell	20K	$122.81
2026-06-09	Noci Darlene	Option exercise	10K	$1.08
2026-06-08	Porter James Richard	Option exercise	30K	$18.93
2026-06-08	Porter James Richard	Sell	3.0K	$89.63
2026-06-08	Porter James Richard	Sell	12K	$87.97
2026-06-08	Porter James Richard	Sell	14K	$88.79
2026-06-01	Balcom Alexandra	Sell	2.2K	$95.99
2026-06-01	Balcom Alexandra	Option exercise	11K	$6.89
2026-06-01	Balcom Alexandra	Sell	960	$94.87
2026-06-01	Balcom Alexandra	Sell	900	$97.68
2026-06-01	Balcom Alexandra	Sell	1.2K	$98.57
2026-06-01	Balcom Alexandra	Sell	3.1K	$99.86
2026-06-01	Balcom Alexandra	Sell	2.6K	$100.65
2026-06-01	Balcom Alexandra	Sell	279	$101.79
2026-06-01	Balcom Alexandra	Sell	200	$103.84
2026-05-28	Miller Deborah Ann	Option exercise	5.5K	$6.89
2026-05-28	Miller Deborah Ann	Sell	1.4K	$106.32
2026-05-28	Miller Deborah Ann	Sell	1.5K	$107.45
2026-05-28	Miller Deborah Ann	Sell	900	$108.14
2026-05-28	Miller Deborah Ann	Sell	1.7K	$109.30
2026-05-28	Noci Darlene	Option exercise	5.5K	$27.85
2026-05-28	Noci Darlene	Sell	1.3K	$106.26
2026-05-28	Noci Darlene	Sell	1.4K	$107.33
2026-05-28	Noci Darlene	Sell	1.2K	$108.01
2026-05-28	Noci Darlene	Sell	1.5K	$109.30
2026-05-28	Noci Darlene	Sell	100	$109.76
2026-05-04	Porter James Richard	Option exercise	30K	$18.93
2026-05-04	Porter James Richard	Sell	1.7K	$98.54
2026-05-04	Porter James Richard	Sell	1.4K	$99.77
2026-05-04	Porter James Richard	Sell	7.4K	$101.48
2026-05-04	Porter James Richard	Sell	17K	$102.10
2026-05-04	Porter James Richard	Sell	2.1K	$102.88
2026-05-01	Balcom Alexandra	Option exercise	7.2K	$1.08
2026-05-01	Balcom Alexandra	Option exercise	4.3K	$6.89
2026-05-01	Balcom Alexandra	Sell	3.9K	$98.42
2026-05-01	Balcom Alexandra	Sell	7.4K	$99.29
2026-05-01	Balcom Alexandra	Sell	124	$99.97
2026-04-30	Miller Deborah Ann	Option exercise	5.5K	$6.89
2026-04-30	Miller Deborah Ann	Sell	4.4K	$99.13
2026-04-30	Miller Deborah Ann	Sell	1.1K	$99.57
2026-04-29	Noci Darlene	Sell	4.5K	$99.35
2026-04-29	Noci Darlene	Option exercise	5.5K	$27.85
2026-04-29	Noci Darlene	Sell	700	$100.14
2026-04-29	Noci Darlene	Sell	300	$101.17
2026-04-09	Pelish Henry E.	Option exercise	3.1K	$27.85
2026-04-09	Pelish Henry E.	Sell	2.2K	$104.27
2026-04-09	Pelish Henry E.	Sell	900	$105.00
2026-04-06	Porter James Richard	Option exercise	14K	$18.93
2026-04-06	Porter James Richard	Option exercise	16K	$27.85
2026-04-06	Porter James Richard	Sell	11K	$103.21
2026-04-06	Porter James Richard	Sell	12K	$103.78
2026-04-06	Porter James Richard	Sell	6.1K	$104.78
2026-04-06	Porter James Richard	Sell	100	$105.60
2026-04-01	Balcom Alexandra	Option exercise	11K	$1.08
2026-04-01	Balcom Alexandra	Sell	3.5K	$104.39
2026-04-01	Balcom Alexandra	Sell	5.4K	$105.30
2026-04-01	Balcom Alexandra	Sell	2.5K	$106.18
2026-04-01	Lane Benjamin	Grant	9.5K	—
2026-03-30	Noci Darlene	Option exercise	5.5K	$27.85
2026-03-30	Noci Darlene	Sell	2.5K	$97.43
2026-03-30	Noci Darlene	Sell	3.0K	$98.13
2026-03-26	Miller Deborah Ann	Sell	940	$97.50
2026-03-26	Miller Deborah Ann	Option exercise	5.5K	$6.89
2026-03-26	Miller Deborah Ann	Sell	1.8K	$98.21
2026-03-26	Miller Deborah Ann	Sell	2.8K	$99.46
2026-03-25	Balcom Alexandra	Sell	14K	$100.16
2026-03-24	Balcom Alexandra	Option exercise	11K	$1.08
2026-03-24	Balcom Alexandra	Sell	2.6K	$95.03
2026-03-24	Balcom Alexandra	Sell	7.7K	$95.88
2026-03-24	Balcom Alexandra	Sell	1.2K	$96.50
2026-03-13	Pelish Henry E.	Sell	2.6K	$98.83
2026-03-13	Pelish Henry E.	Sell	1.7K	$99.71
2026-03-13	Pelish Henry E.	Sell	804	$97.89
2026-03-12	Pelish Henry E.	Sell	24K	$97.79
2026-03-12	Pelish Henry E.	Option exercise	8.5K	$18.93
2026-03-12	Pelish Henry E.	Option exercise	1.8K	$27.85
2026-03-12	Pelish Henry E.	Option exercise	4.1K	$29.33
2026-03-12	Pelish Henry E.	Option exercise	3.0K	$72.35
2026-03-12	Pelish Henry E.	Sell	5.5K	$98.44
2026-03-12	Pelish Henry E.	Sell	306	$99.12
2026-03-06	Porter James Richard	Option exercise	30K	$27.85
2026-03-06	Porter James Richard	Sell	14K	$98.59
2026-03-06	Porter James Richard	Sell	16K	$99.29
2026-03-06	Porter James Richard	Sell	400	$100.19
2026-02-26	Miller Deborah Ann	Sell	2.6K	$103.41
2026-02-26	Noci Darlene	Option exercise	5.5K	$27.85
2026-02-26	Noci Darlene	Sell	3.0K	$102.64
2026-02-26	Noci Darlene	Sell	2.3K	$103.44
2026-02-26	Noci Darlene	Sell	200	$104.25
2026-02-26	Miller Deborah Ann	Option exercise	5.5K	$6.89
2026-02-26	Miller Deborah Ann	Sell	2.7K	$102.64
2026-02-26	Miller Deborah Ann	Sell	200	$103.96
2026-01-29	Noci Darlene	Sell	63	$103.39
2026-01-29	Noci Darlene	Sell	189	$100.95
2026-01-29	Noci Darlene	Option exercise	5.5K	$27.85
2026-01-29	Noci Darlene	Sell	1.8K	$102.67
2026-01-29	Noci Darlene	Sell	3.4K	$101.80
2026-01-22	Miller Deborah Ann	Option exercise	14K	$27.85
2026-01-22	Miller Deborah Ann	Sell	14K	$110.16
2026-01-21	Miller Deborah Ann	Option exercise	700	$27.85
2026-01-21	Miller Deborah Ann	Sell	700	$109.84
2026-01-07	Miller Deborah Ann	Grant	18K	—
2026-01-07	Pelish Henry E.	Grant	18K	—
2026-01-07	Turner Christopher Durant	Grant	18K	—
2026-01-07	Balcom Alexandra	Grant	18K	—
2026-01-07	Porter James Richard	Grant	46K	—
2026-01-07	Noci Darlene	Grant	18K	—
2026-01-06	Miller Deborah Ann	Sell	1.3K	$97.33
2026-01-06	Turner Christopher Durant	Sell	225	$98.40
2026-01-06	Noci Darlene	Sell	1.3K	$96.75
2026-01-06	Noci Darlene	Sell	1.6K	$97.33
2026-01-06	Noci Darlene	Sell	225	$98.40
2026-01-06	Porter James Richard	Sell	4.0K	$96.75
2026-01-06	Porter James Richard	Sell	4.9K	$97.33
2026-01-06	Porter James Richard	Sell	675	$98.40
2026-01-06	Miller Deborah Ann	Sell	183	$98.40
2026-01-06	Pelish Henry E.	Sell	1.1K	$96.75
2026-01-06	Turner Christopher Durant	Sell	1.6K	$97.33
2026-01-06	Turner Christopher Durant	Sell	1.3K	$96.75
2026-01-06	Pelish Henry E.	Sell	189	$98.40
2026-01-06	Pelish Henry E.	Sell	1.4K	$97.33
2026-01-06	Miller Deborah Ann	Sell	1.1K	$96.75
2026-01-06	Balcom Alexandra	Sell	1.3K	$96.75
2026-01-06	Balcom Alexandra	Sell	1.6K	$97.33
2026-01-06	Balcom Alexandra	Sell	225	$98.40
2026-01-05	Porter James Richard	Sell	3.7K	$96.06
2026-01-05	Pelish Henry E.	Sell	513	$96.06
2026-01-05	Pelish Henry E.	Sell	660	$96.85
2026-01-05	Pelish Henry E.	Sell	1.1K	$97.96
2026-01-05	Pelish Henry E.	Sell	186	$98.52
2026-01-05	Noci Darlene	Sell	871	$96.06
2026-01-05	Noci Darlene	Sell	1.1K	$96.85
2026-01-05	Noci Darlene	Sell	1.9K	$97.96
2026-01-05	Noci Darlene	Sell	317	$98.52
2026-01-05	Miller Deborah Ann	Sell	897	$96.06
2026-01-05	Miller Deborah Ann	Sell	1.2K	$96.85
2026-01-05	Miller Deborah Ann	Sell	2.0K	$97.96
2026-01-05	Miller Deborah Ann	Sell	326	$98.52
2026-01-05	Turner Christopher Durant	Sell	871	$96.06
2026-01-05	Turner Christopher Durant	Sell	1.1K	$96.85
2026-01-05	Turner Christopher Durant	Sell	1.9K	$97.96
2026-01-05	Turner Christopher Durant	Sell	317	$98.52
2026-01-05	Balcom Alexandra	Sell	871	$96.06
2026-01-05	Balcom Alexandra	Sell	1.1K	$96.85
2026-01-05	Balcom Alexandra	Sell	1.9K	$97.96
2026-01-05	Balcom Alexandra	Sell	317	$98.52
2026-01-05	Porter James Richard	Sell	4.7K	$96.85
2026-01-05	Porter James Richard	Sell	8.1K	$97.96
2026-01-05	Porter James Richard	Sell	1.3K	$98.52
2026-01-02	Miller Deborah Ann	Option exercise	10K	$18.93
2026-01-02	Miller Deborah Ann	Sell	5.5K	$100.77
2026-01-02	Miller Deborah Ann	Sell	540	$101.47
2026-01-02	Miller Deborah Ann	Sell	4.0K	$100.03
2025-12-30	Noci Darlene	Sell	3.4K	$99.82
2025-12-30	Noci Darlene	Sell	642	$101.22
2025-12-30	Noci Darlene	Option exercise	4.0K	$27.85
2025-12-22	Pelish Henry E.	Option exercise	5.1K	$1.08
2025-12-22	Balcom Alexandra	Option exercise	34K	$1.08
2025-12-19	Porter James Richard	Option exercise	57K	$0.65
2025-12-10	Squarer Ron	Grant	2.8K	—
2025-12-08	Balcom Alexandra	Sell	7.0K	$110.31
2025-12-08	Balcom Alexandra	Sell	100	$111.32
2025-11-28	Noci Darlene	Option exercise	4.0K	$27.85
2025-11-28	Noci Darlene	Sell	645	$107.85
2025-11-28	Noci Darlene	Sell	3.4K	$108.72
2025-11-24	Flynn James E	Sell	371K	$95.44
2025-11-24	Shair Matthew	Sell	369	$107.70
2025-11-24	Shair Matthew	Sell	104	$107.70
2025-11-24	Shair Matthew	Sell	2.3K	$108.73
2025-11-24	Shair Matthew	Sell	638	$108.73
2025-11-24	Shair Matthew	Sell	2.0K	$109.77
2025-11-24	Shair Matthew	Sell	572	$109.77
2025-11-24	Shair Matthew	Sell	1.2K	$110.42
2025-11-24	Shair Matthew	Sell	336	$110.42
2025-11-24	Flynn James E	Sell	371K	$95.44
2025-11-18	Balcom Alexandra	Sell	220	$103.61
2025-11-18	Balcom Alexandra	Sell	509	$104.54
2025-11-18	Balcom Alexandra	Option exercise	729	$72.35
2025-11-17	Balcom Alexandra	Sell	3.3K	$95.12
2025-11-17	Balcom Alexandra	Sell	4.5K	$100.58
2025-11-17	Balcom Alexandra	Sell	3.2K	$102.13
2025-11-17	Balcom Alexandra	Sell	5.1K	$103.27
2025-11-17	Balcom Alexandra	Sell	380	$103.68
2025-11-17	Miller Deborah Ann	Option exercise	24K	$6.89
2025-11-17	Miller Deborah Ann	Sell	15K	$105.16
2025-11-17	Miller Deborah Ann	Sell	8.5K	$105.98
2025-11-17	Balcom Alexandra	Option exercise	6.9K	$6.89
2025-11-17	Miller Deborah Ann	Sell	608	$107.04
2025-11-17	Balcom Alexandra	Option exercise	13K	$72.35
2025-11-17	Balcom Alexandra	Sell	3.6K	$93.80
2025-10-30	Miller Deborah Ann	Sell	700	$96.65
2025-10-30	Noci Darlene	Option exercise	4.0K	$27.85
2025-10-30	Noci Darlene	Sell	57	$98.91
2025-10-30	Noci Darlene	Sell	350	$100.69
2025-10-30	Noci Darlene	Sell	1.2K	$102.07
2025-10-30	Noci Darlene	Sell	1.1K	$103.09
2025-10-30	Noci Darlene	Sell	1.1K	$104.21
2025-10-30	Noci Darlene	Sell	218	$104.58
2025-10-30	Miller Deborah Ann	Option exercise	22K	$6.89
2025-10-30	Miller Deborah Ann	Sell	1.3K	$97.98
2025-10-30	Miller Deborah Ann	Sell	500	$99.66
2025-10-30	Miller Deborah Ann	Sell	600	$100.96
2025-10-30	Miller Deborah Ann	Sell	2.1K	$102.00
2025-10-30	Miller Deborah Ann	Sell	3.7K	$102.88
2025-10-30	Miller Deborah Ann	Sell	3.5K	$103.90
2025-10-30	Miller Deborah Ann	Sell	9.4K	$104.78
2025-10-28	Shair Matthew	Sell	9.2K	$100.27
2025-10-28	Shair Matthew	Sell	32K	$100.27
2025-10-27	Shair Matthew	Sell	4.0K	$100.23
2025-10-27	Shair Matthew	Sell	14K	$100.23
2025-10-20	Miller Deborah Ann	Option exercise	5.0K	$6.89
2025-10-20	Miller Deborah Ann	Sell	5.0K	$94.91
2025-10-16	Porter James Richard	Sell	700	$92.63
2025-10-16	Miller Deborah Ann	Option exercise	12K	$6.89
2025-10-16	Miller Deborah Ann	Sell	5.2K	$91.37
2025-10-16	Miller Deborah Ann	Sell	2.3K	$90.54
2025-10-16	Miller Deborah Ann	Sell	4.9K	$92.50
2025-10-16	Porter James Richard	Option exercise	27K	$18.93
2025-10-16	Porter James Richard	Sell	11K	$90.01
2025-10-16	Porter James Richard	Sell	14K	$90.91
2025-10-16	Porter James Richard	Sell	1.1K	$92.19
2025-10-15	Balcom Alexandra	Sell	1.7K	$85.57
2025-10-15	Miller Deborah Ann	Option exercise	16K	$6.89
2025-10-15	Miller Deborah Ann	Sell	16K	$89.98
2025-10-15	Pelish Henry E.	Option exercise	3.7K	$18.93
2025-10-15	Pelish Henry E.	Option exercise	7.5K	$27.85
2025-10-15	Pelish Henry E.	Option exercise	3.0K	$72.35
2025-10-15	Pelish Henry E.	Sell	14K	$90.04
2025-10-15	Balcom Alexandra	Option exercise	1.7K	$18.93
2025-10-14	Balcom Alexandra	Option exercise	20K	$18.93
2025-10-14	Balcom Alexandra	Sell	12K	$85.75
2025-10-14	Balcom Alexandra	Sell	5.8K	$86.63
2025-10-14	Balcom Alexandra	Sell	1.7K	$87.67
2025-10-14	Balcom Alexandra	Sell	200	$88.90
2025-10-14	Pelish Henry E.	Option exercise	731	$18.93
2025-10-14	Pelish Henry E.	Option exercise	877	$27.85
2025-10-14	Pelish Henry E.	Option exercise	825	$29.33
2025-10-14	Pelish Henry E.	Sell	1.2K	$84.98
2025-10-14	Pelish Henry E.	Sell	866	$86.11
2025-10-14	Pelish Henry E.	Sell	400	$87.39
2025-10-13	Pelish Henry E.	Option exercise	1.7K	$18.93
2025-10-13	Pelish Henry E.	Option exercise	1.8K	$72.35
2025-10-13	Pelish Henry E.	Sell	7.6K	$89.81
2025-10-13	Balcom Alexandra	Option exercise	13K	$18.93
2025-10-13	Balcom Alexandra	Sell	6.1K	$87.90
2025-10-13	Balcom Alexandra	Sell	12K	$88.73
2025-10-13	Balcom Alexandra	Sell	1.6K	$89.22
2025-10-13	Balcom Alexandra	Option exercise	6.9K	$6.89
2025-10-13	Pelish Henry E.	Option exercise	4.2K	$27.85
2025-10-01	Balcom Alexandra	Sell	970	$86.37
2025-10-01	Balcom Alexandra	Option exercise	17K	$6.89
2025-10-01	Balcom Alexandra	Option exercise	3.2K	$18.93
2025-10-01	Balcom Alexandra	Sell	19K	$85.43
2025-09-30	Balcom Alexandra	Sell	20K	$85.06
2025-09-30	Balcom Alexandra	Option exercise	20K	$6.89
2025-09-29	Balcom Alexandra	Option exercise	7.6K	$6.89
2025-09-29	Noci Darlene	Option exercise	4.0K	$27.85
2025-09-29	Noci Darlene	Sell	1.2K	$81.39
2025-09-29	Balcom Alexandra	Sell	7.6K	$85.01
2025-09-29	Noci Darlene	Sell	522	$82.33
2025-09-29	Noci Darlene	Sell	754	$83.20
2025-09-29	Noci Darlene	Sell	1.1K	$84.53
2025-09-29	Noci Darlene	Sell	417	$84.92
2025-09-15	Porter James Richard	Option exercise	27K	$18.93
2025-09-15	Porter James Richard	Sell	8.8K	$78.42
2025-09-15	Porter James Richard	Sell	16K	$79.30
2025-09-15	Porter James Richard	Sell	2.1K	$80.12
2025-09-10	Pelish Henry E.	Option exercise	731	$18.93
2025-09-10	Pelish Henry E.	Option exercise	877	$27.85
2025-09-10	Pelish Henry E.	Option exercise	2.1K	$29.33
2025-09-10	Pelish Henry E.	Sell	3.7K	$78.83
2025-08-29	Pelish Henry E.	Option exercise	2.0K	$0.87
2025-08-29	Pelish Henry E.	Option exercise	3.0K	$1.08
2025-08-25	Noci Darlene	Option exercise	4.0K	$27.85
2025-08-25	Noci Darlene	Sell	1.3K	$73.96
2025-08-25	Noci Darlene	Sell	2.5K	$74.93
2025-08-25	Noci Darlene	Sell	109	$75.63
2025-08-15	Porter James Richard	Sell	100	$76.90
2025-08-15	Porter James Richard	Option exercise	27K	$18.93
2025-08-15	Porter James Richard	Sell	20K	$75.22
2025-08-15	Porter James Richard	Sell	6.9K	$75.98
2025-08-07	Pelish Henry E.	Option exercise	731	$18.93
2025-08-07	Pelish Henry E.	Option exercise	877	$27.85
2025-08-07	Pelish Henry E.	Option exercise	3.9K	$29.33
2025-08-07	Pelish Henry E.	Sell	5.5K	$74.85
2025-07-30	Noci Darlene	Option exercise	4.0K	$27.85
2025-07-30	Noci Darlene	Sell	4.0K	$80.36
2025-07-16	Balcom Alexandra	Sell	15K	$85.10
2025-07-16	Balcom Alexandra	Option exercise	15K	$18.93
2025-07-15	Balcom Alexandra	Sell	2.5K	$82.67
2025-07-15	Balcom Alexandra	Sell	874	$84.91
2025-07-15	Balcom Alexandra	Sell	54	$85.48
2025-07-15	Balcom Alexandra	Option exercise	5.3K	$18.93
2025-07-15	Porter James Richard	Option exercise	27K	$18.93
2025-07-15	Porter James Richard	Sell	5.4K	$81.64
2025-07-15	Porter James Richard	Sell	20K	$82.31
2025-07-15	Porter James Richard	Sell	1.5K	$83.94
2025-07-15	Porter James Richard	Sell	104	$84.53
2025-07-15	Balcom Alexandra	Sell	1.9K	$83.87
2025-07-10	Pelish Henry E.	Option exercise	182	$18.93
2025-07-10	Pelish Henry E.	Option exercise	4.4K	$29.33
2025-07-10	Pelish Henry E.	Sell	5.3K	$79.94
2025-07-10	Pelish Henry E.	Sell	240	$80.92
2025-07-10	Pelish Henry E.	Option exercise	878	$27.85
2025-07-09	Pelish Henry E.	Sell	1.9K	$81.08
2025-07-09	Pelish Henry E.	Sell	200	$81.90
2025-06-27	Balcom Alexandra	Option exercise	20K	$18.93
2025-06-27	Balcom Alexandra	Sell	20K	$80.02
2025-06-27	Pelish Henry E.	Option exercise	347	$27.85
2025-06-27	Pelish Henry E.	Option exercise	1.8K	$29.33
2025-06-27	Pelish Henry E.	Sell	2.2K	$79.92
2025-06-26	Noci Darlene	Sell	306	$79.15
2025-06-26	Noci Darlene	Sell	85	$77.38
2025-06-26	Noci Darlene	Sell	3.6K	$78.70
2025-06-26	Noci Darlene	Option exercise	4.0K	$27.85
2025-06-25	Pelish Henry E.	Sell	8.6K	$79.87
2025-06-25	Pelish Henry E.	Option exercise	5.0K	$29.33
2025-06-25	Pelish Henry E.	Option exercise	3.7K	$27.85
2025-06-18	Meyers Michael L.	Grant	2.6K	—
2025-06-18	Bogle Grant C.	Grant	2.6K	—
2025-06-18	Oliger Christy J.	Grant	4.0K	—
2025-06-18	Protopapas Anna	Grant	2.6K	—
2025-06-18	Flynn James E	Grant	2.6K	—
2025-06-18	Flynn James E	Grant	2.6K	—
2025-06-18	Wheeler Cameron	Grant	2.6K	—
2025-06-18	Srivastava Sapna	Grant	2.6K	—
2025-06-18	Shair Matthew	Grant	2.6K	—
2025-06-18	Pearlberg Joseph	Grant	2.6K	—
2025-06-16	Porter James Richard	Option exercise	27K	$27.85
2025-06-16	Porter James Richard	Sell	15K	$76.66
2025-06-16	Porter James Richard	Sell	12K	$77.26
2025-06-16	Porter James Richard	Sell	200	$78.22
2025-06-06	Pelish Henry E.	Option exercise	100	$27.85
2025-06-06	Pelish Henry E.	Option exercise	100	$29.33
2025-06-06	Pelish Henry E.	Sell	200	$79.82
2025-05-29	Noci Darlene	Option exercise	1.9K	$27.85
2025-05-29	Noci Darlene	Option exercise	2.1K	$14.40
2025-05-29	Noci Darlene	Sell	3.4K	$71.25
2025-05-29	Noci Darlene	Sell	563	$71.67
2025-05-15	Porter James Richard	Option exercise	27K	$27.85
2025-05-15	Porter James Richard	Sell	15K	$69.28
2025-05-15	Porter James Richard	Sell	11K	$69.99
2025-05-15	Porter James Richard	Sell	335	$70.77
2025-04-29	Noci Darlene	Option exercise	4.0K	$14.40
2025-04-29	Noci Darlene	Sell	4.0K	$74.56
2025-04-15	Porter James Richard	Option exercise	27K	$27.85
2025-04-15	Porter James Richard	Sell	11K	$68.31
2025-04-15	Porter James Richard	Sell	11K	$69.05
2025-04-15	Porter James Richard	Sell	4.5K	$70.05
2025-04-15	Porter James Richard	Sell	488	$70.73
2025-03-27	Noci Darlene	Option exercise	2.2K	$18.93
2025-03-27	Noci Darlene	Option exercise	1.8K	$14.40
2025-03-27	Noci Darlene	Sell	3.1K	$72.91
2025-03-27	Noci Darlene	Sell	900	$73.83
2025-03-17	Porter James Richard	Option exercise	27K	$27.85
2025-03-17	Porter James Richard	Sell	10K	$75.29
2025-03-17	Porter James Richard	Sell	16K	$76.20
2025-03-17	Porter James Richard	Sell	601	$76.69
2025-03-07	Noci Darlene	Sell	1.1K	$72.59
2025-03-07	Noci Darlene	Sell	2.9K	$71.68
2025-03-07	Noci Darlene	Option exercise	4.0K	$1.08
2025-03-06	Noci Darlene	Option exercise	22K	$1.08
2025-03-06	Noci Darlene	Option exercise	8.0K	$6.89
2025-03-06	Noci Darlene	Sell	3.7K	$70.65
2025-03-06	Noci Darlene	Sell	22K	$71.92
2025-03-06	Noci Darlene	Sell	4.3K	$72.60
2025-02-24	Shair Matthew	Sell	316	$77.51
2025-02-24	Shair Matthew	Sell	1.4K	$78.49
2025-02-24	Shair Matthew	Sell	302	$79.13
2025-02-18	Porter James Richard	Option exercise	27K	$27.85
2025-02-18	Porter James Richard	Sell	26K	$78.44
2025-02-18	Porter James Richard	Sell	800	$79.01
2025-01-31	Pelish Henry E.	Option exercise	3.1K	$0.87
2025-01-27	Shair Matthew	Sell	1.0K	$82.24
2025-01-27	Shair Matthew	Sell	618	$82.91
2025-01-27	Shair Matthew	Sell	234	$83.88
2025-01-27	Shair Matthew	Sell	108	$85.00
2025-01-15	Porter James Richard	Option exercise	27K	$27.85
2025-01-15	Porter James Richard	Sell	6.3K	$74.94
2025-01-15	Porter James Richard	Sell	9.4K	$75.51
2025-01-15	Porter James Richard	Sell	5.5K	$76.65
2025-01-15	Porter James Richard	Sell	5.8K	$77.28
2025-01-06	Pelish Henry E.	Grant	19K	—
2025-01-06	Pelish Henry E.	Sell	712	$78.28
2025-01-06	Pelish Henry E.	Sell	428	$79.33
2025-01-06	Pelish Henry E.	Sell	1.3K	$80.54
2025-01-06	Noci Darlene	Grant	19K	—
2025-01-06	Noci Darlene	Sell	1.2K	$78.28
2025-01-06	Noci Darlene	Sell	691	$79.33
2025-01-06	Noci Darlene	Sell	2.2K	$80.54
2025-01-06	Miller Deborah Ann	Grant	19K	—
2025-01-06	Miller Deborah Ann	Sell	850	$78.28
2025-01-06	Miller Deborah Ann	Sell	510	$79.33
2025-01-06	Miller Deborah Ann	Sell	1.6K	$80.54
2025-01-06	Turner Christopher Durant	Grant	19K	—
2025-01-06	Turner Christopher Durant	Sell	1.2K	$78.28
2025-01-06	Turner Christopher Durant	Sell	691	$79.33
2025-01-06	Turner Christopher Durant	Sell	2.2K	$80.54
2025-01-06	Balcom Alexandra	Grant	19K	—
2025-01-06	Balcom Alexandra	Sell	1.2K	$78.28
2025-01-06	Balcom Alexandra	Sell	691	$79.33
2025-01-06	Balcom Alexandra	Sell	2.2K	$80.54
2025-01-06	Porter James Richard	Grant	56K	—
2025-01-06	Porter James Richard	Sell	9.4K	$80.54
2025-01-06	Porter James Richard	Sell	3.0K	$79.33
2025-01-06	Porter James Richard	Sell	5.0K	$78.28

All non-derivative Form 4 activity (SEC), newest first.

Clinical trials

Trial	Title	Phase	Status	Primary completion
NCT06765109 ↗	Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC Non-small Cell Lung Cancer, Anaplastic Lymphoma Kinase-positive	PHASE3	Recruiting	2029-12-01
NCT05118789 ↗	A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1) Locally Advanced Solid Tumor, Metastatic Solid Tumor	PHASE1/PHASE2	Recruiting	2027-12-31
NCT05384626 ↗	A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1) Locally Advanced Solid Tumor, Metastatic Solid Tumor	PHASE1/PHASE2	Recruiting	2027-12-01
NCT06521554 ↗	A Study of NVL-330 in Patients With Advanced or Metastatic HER2-altered NSCLC (HEROEX-1) Locally Advanced Solid Tumor, Metastatic Solid Tumor	PHASE1	Recruiting	2027-01-01
NCT06834074 ↗	Expanded Access Program of Neladalkib (NVL-655) for Patients With Advanced ALK+ NSCLC or Other ALK+ Solid Tumors Non Small Cell Lung Cancer, ALK-positive Non-small Cell Lung Cancer (NSCLC)	—	Available
NCT06797362 ↗	Expanded Access Program of Zidesamtinib (NVL-520) for Patients With Advanced ROS1+ NSCLC or Other ROS1+ Solid Tumors Non Small Cell Lung Cancer, ROS1-positive Non-Small Cell Lung Cancer (NSCLC)	—	Available

Source: ClinicalTrials.gov (U.S. NIH) · active studies first.

Notable events (8-K)

Date	Items
2026-06-18	Shareholder vote	filing ↗
2026-06-09	Material agreementReg FDExhibits	filing ↗
2026-05-07	ResultsExhibits	filing ↗
2026-04-07	Other	filing ↗
2026-02-26	ResultsExhibits	filing ↗
2026-01-14	ResultsExhibits	filing ↗
2025-12-16	Other	filing ↗
2025-12-10	Exec/director change	filing ↗

Recent filings

Form	Filed	Period	Accession
8-K	2026-06-18	2026-06-16	0001861560-26-000023 ↗
8-K	2026-06-09	2026-06-09	0001193125-26-262950 ↗
10-Q	2026-05-07	2026-03-31	0001861560-26-000021 ↗
8-K	2026-05-07	2026-05-07	0001861560-26-000020 ↗
8-K	2026-04-07	2026-04-07	0001861560-26-000003 ↗
8-K	2026-02-26	2026-02-26	0001193125-26-073304 ↗
10-K	2026-02-26	2025-12-31	0001193125-26-073317 ↗
8-K	2026-01-14	2026-01-12	0001193125-26-012243 ↗
8-K	2025-12-16	2025-12-16	0001193125-25-320150 ↗
8-K	2025-12-10	2025-12-09	0001193125-25-314165 ↗
8-K	2025-11-20	2025-11-18	0001193125-25-288770 ↗
8-K	2025-11-17	2025-11-17	0001193125-25-283893 ↗