IONIS PHARMACEUTICALS INC
IONS · Pharmaceutical Preparations · 165.3M shares · -2%/yr ↓ buyback · EDGAR filings ↗
Net buyback after stock comp: -$71M (gross $34M, SBC $106M)
Reference price $80.59 · est. market cap ~$13.3B — last insider sale, 2026-06-26 (estimated from the dated SEC Form 4 price × shares outstanding — not a live quote)
Grade
C61Well-capitalized RNA platform transitioning to commercial with an unusually strong run of positive late-stage readouts, still deeply unprofitable.
Strengths
- Broad pipeline validation: positive Phase 3s for olezarsen (FCS), donidalorsen (HAE) and eplontersen, plus positive Phase 2b sHTG — two independent launches underway (TRYNGOLZA, DAWNZERA)
- Strong liquidity: $3.45B cash (97th pct), ~43 quarters runway, 98% gross margin; revenue $944M
Risks
- Still loss-making: net/operating margin ~-40%, ROE -78%, FCF -$320M (4.7th pct), high debt/equity 2.7 (94th)
- Some misses (AGT hypertension, sapablursen thalassemia, GHR acromegaly) and commercialization-execution risk across proximate launches
Notable findings
- No interest coverageInterest coverage -22.11 (cannot cover interest)
- High leverageHigh leverage (debt/equity 2.72)
- Net lossNet loss (net margin -40.4%)
- Cash burnNegative free cash flow (-320.0M)
- Exec changeRecent 8-K item 5.02 8-K ↗
- Fund exitedNotable fund(s) exited this quarter: VANGUARD GROUP INC, Bridgewater Associates, LP
- Trial resultPositive trial readout — primary endpoint met (8-K) 8-K ↗
- Strong balance sheetStrong balance sheet — $3.5B cash & investments, ~43 quarters of runway
- Notable holderHeld by 6 notable fund(s): FMR LLC, STATE STREET CORP, GOLDMAN SACHS GROUP INC +3 more (as of 2026-03-31)
- Insider sellingInsider selling — 90 open-market sale(s) by 16 insider(s) (cluster of 16 insiders, ~$107M, last 6mo) Form 4 ↗
- Trial readout soonUpcoming trial readout ~2026-04 — PHASE3 · Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)
Quarterly revenue
Last 4 quarters · from SEC filings.
Key metrics
Gross margin
98.3%
Operating margin
-40.4%
Net margin
-40.4%
Return on equity
-78.0%
Return on assets
-10.8%
ROIC
-16.6%
Revenue growth (QoQ)
21.0%
Debt / equity
2.7×
Interest coverage
-22.1×
Current ratio
3.8×
Free cash flow
-$320M
Tangible book value
$489M
Cash & investments
$3.5B
Cash runway
43q
Stock comp / revenue
14.2%
Insider transactions · last 18 months
| Date | Insider | Type | Shares | Price |
|---|---|---|---|---|
| 2026-06-26 | Monia Brett P | Option exercise | 50K | $56.78 |
| 2026-06-26 | Monia Brett P | Sell | 50K | $80.59 |
| 2026-06-25 | Swayze Eric | Sell | 11K | $79.18 |
| 2026-06-25 | Monia Brett P | Sell | 21K | $78.49 |
| 2026-06-25 | Monia Brett P | Option exercise | 21K | $32.60 |
| 2026-06-24 | Monia Brett P | Sell | 15K | $78.41 |
| 2026-06-24 | Monia Brett P | Option exercise | 15K | $32.60 |
| 2026-06-15 | BERTHELSEN SPENCER R | Option exercise | 8.0K | $24.42 |
| 2026-06-15 | BERTHELSEN SPENCER R | Sell | 8.0K | $73.49 |
| 2026-06-12 | Kordasiewicz Holly B. | Sell | 20K | $74.05 |
| 2026-06-12 | Kordasiewicz Holly B. | Option exercise | 21K | $60.89 |
| 2026-06-12 | Kordasiewicz Holly B. | Option exercise | 12K | $32.60 |
| 2026-06-12 | Kordasiewicz Holly B. | Option exercise | 20K | $56.78 |
| 2026-06-12 | Kordasiewicz Holly B. | Option exercise | 8.0K | $60.89 |
| 2026-06-12 | Kordasiewicz Holly B. | Sell | 41K | $73.09 |
| 2026-06-01 | BERTHELSEN SPENCER R | Sell | 8.0K | $75.67 |
| 2026-06-01 | BERTHELSEN SPENCER R | Option exercise | 8.0K | $24.42 |
| 2026-05-14 | Monia Brett P | Option exercise | 3.2K | $32.60 |
| 2026-05-14 | Monia Brett P | Sell | 3.2K | $78.68 |
| 2026-05-13 | Monia Brett P | Option exercise | 1.3K | $32.60 |
| 2026-05-13 | Monia Brett P | Sell | 1.3K | $78.01 |
| 2026-05-04 | LOSCALZO JOSEPH | Sell | 18K | $75.58 |
| 2026-05-04 | LOSCALZO JOSEPH | Option exercise | 12K | $40.05 |
| 2026-05-04 | LOSCALZO JOSEPH | Option exercise | 10K | $41.08 |
| 2026-05-04 | LOSCALZO JOSEPH | Option exercise | 16K | $42.88 |
| 2026-05-04 | LOSCALZO JOSEPH | Option exercise | 12K | $60.20 |
| 2026-05-04 | LOSCALZO JOSEPH | Option exercise | 16K | $64.80 |
| 2026-05-04 | LOSCALZO JOSEPH | Sell | 60K | $74.90 |
| 2026-05-04 | LOSCALZO JOSEPH | Option exercise | 11K | $38.06 |
| 2026-05-01 | KLEIN JOSEPH III | Sell | 8.7K | $73.35 |
| 2026-05-01 | KLEIN JOSEPH III | Sell | 1.4K | $74.45 |
| 2026-05-01 | KLEIN JOSEPH III | Option exercise | 10K | $47.11 |
| 2026-04-28 | Baroldi Joseph | Sell | 1.6K | $71.79 |
| 2026-04-16 | Jenne Kyle | Sell | 4.9K | $75.17 |
| 2026-04-16 | Baroldi Joseph | Sell | 5.6K | $74.56 |
| 2026-04-16 | Birchler Brian | Sell | 973 | $75.04 |
| 2026-04-15 | Birchler Brian | Option exercise | 1.9K | — |
| 2026-04-15 | PARSHALL B LYNNE | Sell | 4.5K | $76.19 |
| 2026-04-15 | PARSHALL B LYNNE | Sell | 534 | $76.97 |
| 2026-04-15 | Jenne Kyle | Option exercise | 12K | — |
| 2026-04-15 | Baroldi Joseph | Option exercise | 11K | — |
| 2026-04-02 | Devers Shannon L. | Sell | 6.2K | $74.05 |
| 2026-04-01 | KLEIN JOSEPH III | Option exercise | 12K | $38.06 |
| 2026-04-01 | KLEIN JOSEPH III | Sell | 2.2K | $75.95 |
| 2026-04-01 | KLEIN JOSEPH III | Sell | 20K | $75.50 |
| 2026-04-01 | KLEIN JOSEPH III | Option exercise | 10K | $41.08 |
| 2026-03-19 | Schneider Eugene | Sell | 5.8K | $70.97 |
| 2026-03-17 | HOUGEN ELIZABETH L | Sell | 10K | $73.21 |
| 2026-03-16 | HOUGEN ELIZABETH L | Option exercise | 33K | $32.60 |
| 2026-03-16 | HOUGEN ELIZABETH L | Sell | 9.4K | $72.77 |
| 2026-03-16 | HOUGEN ELIZABETH L | Option exercise | 60K | $60.89 |
| 2026-03-16 | HOUGEN ELIZABETH L | Option exercise | 61K | $56.78 |
| 2026-03-16 | HOUGEN ELIZABETH L | Option exercise | 21K | $37.58 |
| 2026-03-16 | HOUGEN ELIZABETH L | Sell | 206K | $72.38 |
| 2026-03-10 | Monia Brett P | Sell | 17K | $75.47 |
| 2026-03-10 | Monia Brett P | Sell | 18K | $76.34 |
| 2026-03-10 | Jenne Kyle | Option exercise | 33K | $46.10 |
| 2026-03-10 | Jenne Kyle | Sell | 21K | $75.50 |
| 2026-03-10 | Jenne Kyle | Option exercise | 4.7K | $34.69 |
| 2026-03-10 | Jenne Kyle | Sell | 16K | $76.30 |
| 2026-03-10 | Monia Brett P | Option exercise | 34K | $60.89 |
| 2026-03-09 | Monia Brett P | Sell | 1.7K | $75.58 |
| 2026-03-09 | O'NEIL PATRICK R. | Sell | 10K | $75.25 |
| 2026-03-09 | Monia Brett P | Option exercise | 41K | $60.89 |
| 2026-03-09 | Monia Brett P | Option exercise | 74K | $60.89 |
| 2026-03-09 | Monia Brett P | Sell | 7.4K | $74.11 |
| 2026-03-09 | Monia Brett P | Sell | 118K | $75.26 |
| 2026-03-04 | Baroldi Joseph | Sell | 238 | $80.00 |
| 2026-03-04 | Baroldi Joseph | Option exercise | 201 | $32.60 |
| 2026-03-04 | LOSCALZO JOSEPH | Sell | 200 | $80.00 |
| 2026-03-04 | LOSCALZO JOSEPH | Option exercise | 200 | $38.06 |
| 2026-03-04 | Baroldi Joseph | Sell | 201 | $80.00 |
| 2026-03-04 | Baroldi Joseph | Option exercise | 238 | $56.78 |
| 2026-03-03 | Diaz Allene M. | Sell | 15K | $79.88 |
| 2026-03-03 | Diaz Allene M. | Sell | 1.0K | $80.80 |
| 2026-03-03 | Devers Shannon L. | Option exercise | 3.5K | $37.58 |
| 2026-03-03 | Devers Shannon L. | Option exercise | 3.8K | $40.85 |
| 2026-03-03 | Devers Shannon L. | Option exercise | 5.5K | $34.69 |
| 2026-03-03 | Devers Shannon L. | Option exercise | 7.0K | $32.60 |
| 2026-03-03 | Devers Shannon L. | Option exercise | 385 | $52.87 |
| 2026-03-03 | Devers Shannon L. | Sell | 14K | $79.11 |
| 2026-03-03 | Devers Shannon L. | Sell | 5.0K | $80.00 |
| 2026-03-03 | Devers Shannon L. | Sell | 755 | $80.84 |
| 2026-03-03 | BENNETT C FRANK | Option exercise | 16K | $32.60 |
| 2026-03-03 | BENNETT C FRANK | Option exercise | 49K | $60.89 |
| 2026-03-03 | BENNETT C FRANK | Sell | 72K | $79.10 |
| 2026-03-03 | BENNETT C FRANK | Sell | 13K | $79.88 |
| 2026-03-03 | BENNETT C FRANK | Sell | 802 | $80.76 |
| 2026-03-03 | Baroldi Joseph | Sell | 4.1K | $79.36 |
| 2026-03-03 | Baroldi Joseph | Option exercise | 820 | $56.78 |
| 2026-03-03 | Baroldi Joseph | Option exercise | 879 | $32.60 |
| 2026-03-03 | Baroldi Joseph | Sell | 2.1K | $80.41 |
| 2026-03-03 | Baroldi Joseph | Sell | 36 | $81.01 |
| 2026-03-03 | KLEIN JOSEPH III | Sell | 14K | $79.17 |
| 2026-03-03 | KLEIN JOSEPH III | Option exercise | 4.0K | $42.88 |
| 2026-03-03 | KLEIN JOSEPH III | Option exercise | 12K | $40.05 |
| 2026-03-03 | LOSCALZO JOSEPH | Sell | 832 | $80.33 |
| 2026-03-03 | KLEIN JOSEPH III | Sell | 6.8K | $80.00 |
| 2026-03-03 | LOSCALZO JOSEPH | Option exercise | 832 | $38.06 |
| 2026-03-03 | KLEIN JOSEPH III | Sell | 1.0K | $80.82 |
| 2026-03-03 | Diaz Allene M. | Option exercise | 10K | $41.08 |
| 2026-03-03 | Diaz Allene M. | Option exercise | 12K | $38.06 |
| 2026-03-03 | Diaz Allene M. | Option exercise | 18K | $40.05 |
| 2026-03-03 | Diaz Allene M. | Sell | 39K | $79.11 |
| 2026-02-27 | Birchler Brian | Other | 351 | $48.87 |
| 2026-02-27 | Swayze Eric | Other | 256 | $48.87 |
| 2026-02-27 | O'NEIL PATRICK R. | Other | 376 | $48.87 |
| 2026-02-27 | Monia Brett P | Other | 484 | $48.87 |
| 2026-02-27 | BENNETT C FRANK | Other | 261 | $48.87 |
| 2026-02-13 | Swayze Eric | Sell | 9.4K | $81.56 |
| 2026-02-13 | Swayze Eric | Sell | 6.2K | $82.07 |
| 2026-02-11 | PARSHALL B LYNNE | Sell | 5.0K | $82.72 |
| 2026-02-06 | Monia Brett P | Sell | 29K | $85.79 |
| 2026-02-02 | BENNETT C FRANK | Option exercise | 16K | $32.60 |
| 2026-02-02 | BENNETT C FRANK | Option exercise | 49K | $60.89 |
| 2026-02-02 | BENNETT C FRANK | Sell | 49K | $83.03 |
| 2026-02-02 | BENNETT C FRANK | Other | 0 | — |
| 2026-02-02 | BENNETT C FRANK | Sell | 16K | $83.03 |
| 2026-02-02 | BENNETT C FRANK | Sell | 20K | $82.60 |
| 2026-01-30 | Monia Brett P | Sell | 63K | $82.72 |
| 2026-01-30 | HOUGEN ELIZABETH L | Sell | 7.0K | $83.24 |
| 2026-01-30 | Birchler Brian | Sell | 6.2K | $83.03 |
| 2026-01-30 | BENNETT C FRANK | Sell | 5.9K | $82.95 |
| 2026-01-30 | Baroldi Joseph | Sell | 5.3K | $82.96 |
| 2026-01-30 | Swayze Eric | Sell | 6.2K | $82.93 |
| 2026-01-30 | Schneider Eugene | Sell | 6.2K | $83.45 |
| 2026-01-30 | O'NEIL PATRICK R. | Sell | 6.2K | $83.53 |
| 2026-01-29 | Baroldi Joseph | Grant | 10K | — |
| 2026-01-29 | Schneider Eugene | Grant | 12K | — |
| 2026-01-29 | O'NEIL PATRICK R. | Grant | 12K | — |
| 2026-01-29 | Monia Brett P | Grant | 122K | — |
| 2026-01-29 | Birchler Brian | Grant | 12K | — |
| 2026-01-29 | Swayze Eric | Grant | 12K | — |
| 2026-01-29 | BENNETT C FRANK | Grant | 11K | — |
| 2026-01-29 | HOUGEN ELIZABETH L | Grant | 14K | — |
| 2026-01-22 | Devers Shannon L. | Sell | 4.0K | $81.34 |
| 2026-01-16 | Kordasiewicz Holly B. | Sell | 4.1K | $75.66 |
| 2026-01-16 | Birchler Brian | Sell | 8.5K | $75.11 |
| 2026-01-16 | Baroldi Joseph | Sell | 1.1K | $75.78 |
| 2026-01-16 | Jenne Kyle | Sell | 1.8K | $75.96 |
| 2026-01-16 | Devers Shannon L. | Sell | 8.4K | $75.95 |
| 2026-01-16 | Baroldi Joseph | Sell | 6.9K | $75.75 |
| 2026-01-16 | BENNETT C FRANK | Sell | 9.0K | $75.15 |
| 2026-01-16 | Swayze Eric | Sell | 9.9K | $75.34 |
| 2026-01-16 | Swayze Eric | Sell | 49 | $75.97 |
| 2026-01-16 | Schneider Eugene | Sell | 9.3K | $75.59 |
| 2026-01-16 | O'NEIL PATRICK R. | Sell | 9.2K | $75.84 |
| 2026-01-16 | HOUGEN ELIZABETH L | Sell | 13K | $75.22 |
| 2026-01-16 | Monia Brett P | Sell | 44K | $74.82 |
| 2026-01-15 | HOUGEN ELIZABETH L | Option exercise | 29K | — |
| 2026-01-15 | YANG MICHAEL J. | Option exercise | 1.9K | — |
| 2026-01-15 | Swayze Eric | Option exercise | 21K | — |
| 2026-01-15 | Swayze Eric | Option exercise | 111 | — |
| 2026-01-15 | Schneider Eugene | Option exercise | 22K | — |
| 2026-01-15 | O'NEIL PATRICK R. | Option exercise | 21K | — |
| 2026-01-15 | Monia Brett P | Option exercise | 89K | — |
| 2026-01-15 | Kordasiewicz Holly B. | Option exercise | 11K | — |
| 2026-01-15 | Jenne Kyle | Option exercise | 7.0K | — |
| 2026-01-15 | Devers Shannon L. | Option exercise | 17K | — |
| 2026-01-15 | Birchler Brian | Option exercise | 20K | — |
| 2026-01-15 | BENNETT C FRANK | Option exercise | 21K | — |
| 2026-01-15 | Baroldi Joseph | Option exercise | 17K | — |
| 2026-01-15 | Baroldi Joseph | Option exercise | 2.9K | — |
| 2026-01-07 | Devers Shannon L. | Sell | 3.8K | $84.62 |
| 2026-01-07 | Devers Shannon L. | Option exercise | 9.3K | $52.87 |
| 2026-01-07 | Devers Shannon L. | Sell | 9.3K | $84.62 |
| 2026-01-07 | Devers Shannon L. | Option exercise | 3.8K | $37.58 |
| 2026-01-07 | Devers Shannon L. | Sell | 3.5K | $84.62 |
| 2026-01-07 | Devers Shannon L. | Option exercise | 3.5K | $32.60 |
| 2026-01-07 | Devers Shannon L. | Sell | 2.1K | $85.36 |
| 2026-01-07 | Devers Shannon L. | Option exercise | 2.1K | $32.60 |
| 2026-01-07 | Devers Shannon L. | Sell | 26K | $85.36 |
| 2026-01-07 | Devers Shannon L. | Option exercise | 26K | $56.78 |
| 2026-01-02 | Swayze Eric | Sell | 18K | $79.27 |
| 2026-01-02 | Swayze Eric | Option exercise | 18K | $60.89 |
| 2026-01-02 | Swayze Eric | Sell | 5.1K | $78.57 |
| 2026-01-02 | Swayze Eric | Option exercise | 5.1K | $60.89 |
| 2025-12-01 | WENDER JOSEPH H | Sell | 7.4K | $81.23 |
| 2025-12-01 | WENDER JOSEPH H | Sell | 21K | $80.67 |
| 2025-11-25 | Devers Shannon L. | Sell | 17K | $80.91 |
| 2025-11-25 | KLEIN JOSEPH III | Sell | 4.0K | $80.00 |
| 2025-11-25 | KLEIN JOSEPH III | Option exercise | 4.0K | — |
| 2025-11-25 | KLEIN JOSEPH III | Sell | 4.0K | $80.00 |
| 2025-11-25 | KLEIN JOSEPH III | Option exercise | 4.0K | — |
| 2025-11-25 | KLEIN JOSEPH III | Sell | 4.0K | $80.00 |
| 2025-11-25 | Devers Shannon L. | Option exercise | 17K | $53.77 |
| 2025-11-25 | KLEIN JOSEPH III | Option exercise | 4.0K | — |
| 2025-11-19 | HERMAN JOAN E | Sell | 12K | $72.13 |
| 2025-11-19 | HERMAN JOAN E | Option exercise | 12K | $40.05 |
| 2025-11-19 | HERMAN JOAN E | Sell | 32K | $72.13 |
| 2025-11-19 | HERMAN JOAN E | Option exercise | 32K | $63.90 |
| 2025-11-18 | WENDER JOSEPH H | Option exercise | 16K | $24.42 |
| 2025-11-06 | Geary Richard S | Sell | 15K | $76.10 |
| 2025-11-06 | Geary Richard S | Option exercise | 18K | $60.89 |
| 2025-11-06 | Geary Richard S | Sell | 18K | $75.42 |
| 2025-11-06 | Birchler Brian | Sell | 8.0K | $76.17 |
| 2025-11-06 | Geary Richard S | Option exercise | 15K | $56.78 |
| 2025-11-05 | Geary Richard S | Option exercise | 800 | $56.78 |
| 2025-11-05 | Geary Richard S | Option exercise | 801 | $60.89 |
| 2025-11-05 | Geary Richard S | Sell | 801 | $75.01 |
| 2025-11-05 | Geary Richard S | Sell | 800 | $75.01 |
| 2025-11-03 | Geary Richard S | Sell | 905 | $75.05 |
| 2025-11-03 | Geary Richard S | Option exercise | 775 | $60.89 |
| 2025-11-03 | Geary Richard S | Sell | 775 | $75.05 |
| 2025-11-03 | Geary Richard S | Option exercise | 905 | $56.78 |
| 2025-11-03 | Geary Richard S | Option exercise | 775 | $56.78 |
| 2025-11-03 | Geary Richard S | Sell | 775 | $75.05 |
| 2025-11-03 | Geary Richard S | Option exercise | 905 | $60.89 |
| 2025-11-03 | Geary Richard S | Sell | 905 | $75.05 |
| 2025-10-31 | Geary Richard S | Option exercise | 35K | $56.78 |
| 2025-10-31 | Geary Richard S | Sell | 35K | $75.11 |
| 2025-10-31 | Geary Richard S | Sell | 20K | $75.11 |
| 2025-10-31 | WENDER JOSEPH H | Sell | 11K | $75.16 |
| 2025-10-31 | Geary Richard S | Option exercise | 35K | $60.89 |
| 2025-10-31 | LOSCALZO JOSEPH | Sell | 16K | $75.10 |
| 2025-10-31 | LOSCALZO JOSEPH | Option exercise | 16K | $52.22 |
| 2025-10-31 | Geary Richard S | Sell | 35K | $75.11 |
| 2025-10-30 | WENDER JOSEPH H | Sell | 6.0K | $73.85 |
| 2025-10-30 | WENDER JOSEPH H | Sell | 8.3K | $73.16 |
| 2025-10-30 | WENDER JOSEPH H | Sell | 2.5K | $72.19 |
| 2025-10-16 | Devers Shannon L. | Sell | 1.3K | $73.62 |
| 2025-10-16 | Swayze Eric | Sell | 53 | $73.62 |
| 2025-10-15 | Birchler Brian | Option exercise | 12K | $53.77 |
| 2025-10-15 | Swayze Eric | Option exercise | 125 | — |
| 2025-10-15 | Birchler Brian | Sell | 12K | $72.23 |
| 2025-10-15 | Devers Shannon L. | Option exercise | 2.8K | — |
| 2025-10-15 | PARSHALL B LYNNE | Sell | 5.0K | $71.74 |
| 2025-10-15 | Devers Shannon L. | Option exercise | 6.0K | $48.51 |
| 2025-10-15 | Devers Shannon L. | Sell | 6.0K | $72.94 |
| 2025-10-14 | Birchler Brian | Sell | 11K | $72.03 |
| 2025-10-14 | Birchler Brian | Option exercise | 11K | $53.77 |
| 2025-10-06 | O'NEIL PATRICK R. | Sell | 10K | $69.89 |
| 2025-10-06 | Monia Brett P | Sell | 437 | $69.26 |
| 2025-10-06 | Baroldi Joseph | Sell | 1.6K | $69.37 |
| 2025-10-06 | Swayze Eric | Sell | 6.8K | $69.02 |
| 2025-10-06 | O'NEIL PATRICK R. | Option exercise | 10K | $52.87 |
| 2025-10-06 | O'NEIL PATRICK R. | Sell | 3.2K | $69.27 |
| 2025-10-02 | Swayze Eric | Option exercise | 13K | $53.77 |
| 2025-10-02 | Baroldi Joseph | Sell | 15K | $68.01 |
| 2025-10-02 | Swayze Eric | Sell | 13K | $66.23 |
| 2025-10-02 | O'NEIL PATRICK R. | Option exercise | 30K | $56.78 |
| 2025-10-02 | O'NEIL PATRICK R. | Sell | 30K | $67.69 |
| 2025-10-02 | O'NEIL PATRICK R. | Option exercise | 34K | $60.89 |
| 2025-10-02 | O'NEIL PATRICK R. | Sell | 34K | $67.69 |
| 2025-10-02 | Baroldi Joseph | Option exercise | 15K | $31.80 |
| 2025-10-01 | Swayze Eric | Option exercise | 14K | $53.77 |
| 2025-10-01 | WENDER JOSEPH H | Sell | 17K | $65.50 |
| 2025-10-01 | Swayze Eric | Sell | 14K | $66.09 |
| 2025-09-30 | HOUGEN ELIZABETH L | Option exercise | 50K | $53.77 |
| 2025-09-30 | HOUGEN ELIZABETH L | Sell | 50K | $65.26 |
| 2025-09-30 | O'NEIL PATRICK R. | Option exercise | 15K | $56.78 |
| 2025-09-30 | O'NEIL PATRICK R. | Sell | 15K | $64.68 |
| 2025-09-30 | Geary Richard S | Option exercise | 58K | $53.77 |
| 2025-09-30 | Geary Richard S | Sell | 58K | $65.24 |
| 2025-09-29 | O'NEIL PATRICK R. | Option exercise | 10K | $56.78 |
| 2025-09-29 | O'NEIL PATRICK R. | Sell | 10K | $64.54 |
| 2025-09-12 | O'NEIL PATRICK R. | Sell | 1.7K | $64.58 |
| 2025-09-12 | O'NEIL PATRICK R. | Option exercise | 1.7K | $56.78 |
| 2025-09-09 | O'NEIL PATRICK R. | Option exercise | 1.0K | $56.78 |
| 2025-09-09 | Baroldi Joseph | Sell | 12K | $62.16 |
| 2025-09-09 | Baroldi Joseph | Option exercise | 12K | $31.80 |
| 2025-09-09 | O'NEIL PATRICK R. | Sell | 1.0K | $64.56 |
| 2025-09-09 | O'NEIL PATRICK R. | Sell | 20K | $64.56 |
| 2025-09-09 | O'NEIL PATRICK R. | Option exercise | 20K | $60.89 |
| 2025-09-05 | BENNETT C FRANK | Sell | 6.0K | $59.60 |
| 2025-09-05 | Baroldi Joseph | Sell | 250 | $62.00 |
| 2025-09-05 | Baroldi Joseph | Option exercise | 250 | $31.80 |
| 2025-09-03 | KLEIN JOSEPH III | Option exercise | 12K | — |
| 2025-09-03 | WENDER JOSEPH H | Sell | 11K | $60.14 |
| 2025-09-03 | Monia Brett P | Option exercise | 103K | $53.77 |
| 2025-09-03 | Monia Brett P | Sell | 17K | $59.12 |
| 2025-09-03 | Monia Brett P | Option exercise | 42K | $37.58 |
| 2025-09-03 | Monia Brett P | Sell | 128K | $60.13 |
| 2025-09-03 | Monia Brett P | Option exercise | 31K | $32.60 |
| 2025-09-03 | Monia Brett P | Option exercise | 28K | $32.60 |
| 2025-09-03 | Monia Brett P | Sell | 60K | $61.06 |
| 2025-09-03 | KLEIN JOSEPH III | Option exercise | 16K | — |
| 2025-09-03 | KLEIN JOSEPH III | Option exercise | 12K | — |
| 2025-09-03 | KLEIN JOSEPH III | Sell | 28K | $60.00 |
| 2025-09-03 | KLEIN JOSEPH III | Option exercise | 16K | — |
| 2025-09-03 | KLEIN JOSEPH III | Sell | 28K | $60.00 |
| 2025-09-03 | Devers Shannon L. | Option exercise | 2.2K | $37.58 |
| 2025-09-03 | Devers Shannon L. | Sell | 3.2K | $61.02 |
| 2025-09-03 | Devers Shannon L. | Option exercise | 928 | $32.60 |
| 2025-09-03 | WENDER JOSEPH H | Sell | 11K | $60.14 |
| 2025-09-03 | Baroldi Joseph | Option exercise | 2.8K | $31.80 |
| 2025-09-03 | Baroldi Joseph | Sell | 2.8K | $62.01 |
| 2025-09-03 | Baroldi Joseph | Option exercise | 15K | $31.80 |
| 2025-09-03 | Baroldi Joseph | Sell | 30K | $59.09 |
| 2025-09-03 | Baroldi Joseph | Option exercise | 15K | $31.80 |
| 2025-09-03 | O'NEIL PATRICK R. | Option exercise | 14K | $37.58 |
| 2025-09-03 | O'NEIL PATRICK R. | Sell | 65K | $60.89 |
| 2025-09-03 | O'NEIL PATRICK R. | Option exercise | 13K | $32.60 |
| 2025-09-03 | O'NEIL PATRICK R. | Sell | 11K | $61.42 |
| 2025-09-03 | O'NEIL PATRICK R. | Option exercise | 50K | $53.77 |
| 2025-09-03 | BENNETT C FRANK | Option exercise | 47K | $53.77 |
| 2025-09-03 | BENNETT C FRANK | Sell | 34K | $60.62 |
| 2025-09-03 | BENNETT C FRANK | Option exercise | 13K | $61.50 |
| 2025-09-03 | LOSCALZO JOSEPH | Option exercise | 16K | $24.42 |
| 2025-09-03 | LOSCALZO JOSEPH | Sell | 16K | $60.15 |
| 2025-09-03 | Schneider Eugene | Option exercise | 20K | $53.77 |
| 2025-09-03 | Schneider Eugene | Sell | 12K | $60.46 |
| 2025-09-03 | Schneider Eugene | Sell | 7.2K | $61.42 |
| 2025-09-02 | BENNETT C FRANK | Sell | 5.0K | $49.14 |
| 2025-09-02 | WENDER JOSEPH H | Sell | 11K | $55.04 |
| 2025-09-02 | Geary Richard S | Sell | 10K | $50.37 |
| 2025-09-02 | WENDER JOSEPH H | Sell | 5.6K | $57.53 |
| 2025-09-02 | PARSHALL B LYNNE | Sell | 9.2K | $51.49 |
| 2025-09-02 | WENDER JOSEPH H | Sell | 11K | $55.04 |
| 2025-09-02 | Swayze Eric | Sell | 10K | $49.22 |
| 2025-09-02 | O'NEIL PATRICK R. | Option exercise | 13K | $32.60 |
| 2025-09-02 | WENDER JOSEPH H | Sell | 5.6K | $57.53 |
| 2025-09-02 | PARSHALL B LYNNE | Sell | 11K | $50.42 |
| 2025-09-02 | O'NEIL PATRICK R. | Sell | 13K | $54.51 |
| 2025-09-02 | Swayze Eric | Sell | 1.1K | $53.68 |
| 2025-08-29 | Monia Brett P | Other | 189 | $27.71 |
| 2025-08-29 | O'NEIL PATRICK R. | Other | 331 | $27.71 |
| 2025-08-29 | Geary Richard S | Other | 165 | $27.71 |
| 2025-08-29 | BENNETT C FRANK | Other | 213 | $27.71 |
| 2025-08-29 | Birchler Brian | Other | 166 | $27.71 |
| 2025-08-22 | Diaz Allene M. | Sell | 1.4K | $42.53 |
| 2025-08-18 | BENNETT C FRANK | Option exercise | 10K | $32.60 |
| 2025-08-18 | BENNETT C FRANK | Sell | 10K | $43.98 |
| 2025-08-06 | PARSHALL B LYNNE | Sell | 400 | $42.63 |
| 2025-08-06 | PARSHALL B LYNNE | Sell | 4.6K | $41.87 |
| 2025-08-05 | Geary Richard S | Sell | 10K | $42.86 |
| 2025-08-04 | Schneider Eugene | Sell | 9.5K | $42.80 |
| 2025-07-30 | Monia Brett P | Option exercise | 2.4K | $32.60 |
| 2025-07-30 | Monia Brett P | Sell | 2.4K | $45.00 |
| 2025-07-15 | BERTHELSEN SPENCER R | Option exercise | 4.1K | — |
| 2025-07-15 | Diaz Allene M. | Option exercise | 4.1K | — |
| 2025-07-15 | Hayden Michael R | Option exercise | 4.1K | — |
| 2025-07-15 | HERMAN JOAN E | Option exercise | 4.1K | — |
| 2025-07-15 | PARSHALL B LYNNE | Option exercise | 4.1K | — |
| 2025-07-15 | WENDER JOSEPH H | Option exercise | 4.1K | — |
| 2025-07-15 | YANG MICHAEL J. | Option exercise | 4.1K | — |
| 2025-07-15 | LOSCALZO JOSEPH | Option exercise | 4.1K | — |
| 2025-07-11 | Monia Brett P | Sell | 1.2K | $41.74 |
| 2025-05-01 | Hayden Michael R | Buy | 15K | $31.86 |
| 2025-04-16 | Baroldi Joseph | Sell | 3.9K | $28.40 |
| 2025-04-16 | Jenne Kyle | Sell | 3.0K | $28.36 |
| 2025-04-16 | Birchler Brian | Sell | 680 | $28.37 |
| 2025-04-15 | Baroldi Joseph | Option exercise | 11K | — |
| 2025-04-15 | Birchler Brian | Option exercise | 1.9K | — |
| 2025-04-15 | Jenne Kyle | Option exercise | 12K | — |
| 2025-03-11 | Monia Brett P | Sell | 140 | $32.32 |
| 2025-02-28 | BENNETT C FRANK | Other | 320 | $28.21 |
| 2025-02-28 | Swayze Eric | Other | 415 | $28.21 |
| 2025-02-28 | O'NEIL PATRICK R. | Other | 554 | $28.21 |
| 2025-02-28 | Birchler Brian | Other | 414 | $28.21 |
| 2025-02-28 | Geary Richard S | Other | 415 | $28.21 |
| 2025-02-28 | Monia Brett P | Other | 437 | $28.21 |
| 2025-02-20 | O'NEIL PATRICK R. | Sell | 1.2K | $32.35 |
| 2025-02-04 | Monia Brett P | Sell | 39K | $31.65 |
| 2025-02-04 | O'NEIL PATRICK R. | Sell | 6.2K | $31.62 |
| 2025-01-31 | Geary Richard S | Sell | 1.4K | $32.40 |
| 2025-01-31 | Swayze Eric | Sell | 1.4K | $32.31 |
| 2025-01-31 | Schneider Eugene | Sell | 1.5K | $32.20 |
| 2025-01-31 | O'NEIL PATRICK R. | Sell | 1.4K | $32.49 |
| 2025-01-31 | Monia Brett P | Sell | 13K | $32.45 |
| 2025-01-31 | HOUGEN ELIZABETH L | Sell | 1.5K | $32.44 |
| 2025-01-31 | BENNETT C FRANK | Sell | 1.3K | $32.46 |
| 2025-01-30 | Monia Brett P | Grant | 25K | — |
| 2025-01-30 | Swayze Eric | Grant | 3.7K | — |
| 2025-01-30 | HOUGEN ELIZABETH L | Grant | 4.1K | — |
| 2025-01-30 | O'NEIL PATRICK R. | Grant | 3.8K | — |
| 2025-01-30 | Geary Richard S | Grant | 3.8K | — |
| 2025-01-30 | Schneider Eugene | Grant | 4.0K | — |
| 2025-01-30 | BENNETT C FRANK | Grant | 3.6K | — |
| 2025-01-16 | Geary Richard S | Sell | 7.1K | $32.86 |
| 2025-01-16 | Swayze Eric | Sell | 7.2K | $32.84 |
| 2025-01-16 | Swayze Eric | Sell | 22 | $32.70 |
| 2025-01-16 | Schneider Eugene | Sell | 6.5K | $32.79 |
| 2025-01-16 | O'NEIL PATRICK R. | Sell | 7.4K | $32.83 |
| 2025-01-16 | Monia Brett P | Sell | 33K | $32.63 |
| 2025-01-16 | HOUGEN ELIZABETH L | Sell | 8.9K | $32.81 |
| 2025-01-16 | Devers Shannon L. | Sell | 4.3K | $32.78 |
| 2025-01-16 | Birchler Brian | Sell | 5.4K | $32.70 |
| 2025-01-16 | BENNETT C FRANK | Sell | 6.8K | $32.90 |
| 2025-01-16 | Baroldi Joseph | Sell | 3.4K | $32.70 |
| 2025-01-16 | Baroldi Joseph | Sell | 1.0K | $32.70 |
| 2025-01-15 | Birchler Brian | Option exercise | 14K | — |
| 2025-01-15 | Schneider Eugene | Option exercise | 17K | — |
| 2025-01-15 | Monia Brett P | Option exercise | 73K | — |
| 2025-01-15 | O'NEIL PATRICK R. | Option exercise | 20K | — |
| 2025-01-15 | BENNETT C FRANK | Option exercise | 18K | — |
| 2025-01-15 | Swayze Eric | Option exercise | 19K | — |
| 2025-01-15 | Baroldi Joseph | Option exercise | 8.8K | — |
| 2025-01-15 | Swayze Eric | Option exercise | 49 | — |
| 2025-01-15 | HOUGEN ELIZABETH L | Option exercise | 24K | — |
| 2025-01-15 | Geary Richard S | Option exercise | 19K | — |
| 2025-01-15 | YANG MICHAEL J. | Option exercise | 1.9K | — |
| 2025-01-15 | Devers Shannon L. | Option exercise | 12K | — |
| 2025-01-15 | Baroldi Joseph | Option exercise | 2.5K | — |
All non-derivative Form 4 activity (SEC), newest first.
Clinical trials
| Trial | Title | Phase | Status | Primary completion |
|---|---|---|---|---|
| NCT07531745 ↗ | ASCEND: Safety and Tolerability of ION337 for the Treatment of Dravet Syndrome Dravet Syndrome | PHASE1/PHASE2 | Recruiting | 2030-12-01 |
| NCT05071300 ↗ | A Study to Assess the Long-Term Safety and Efficacy of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Patients With Hereditary Transthyretin-Mediated Amyloid Polyneuropathy Hereditary Transthyretin-Mediated Amyloid Polyneuropathy | PHASE3 | Active Not Recruiting | 2029-08-01 |
| NCT05667493 ↗ | An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM) Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM) | PHASE3 | Enrolling By Invitation | 2029-08-01 |
| NCT07298447 ↗ | Donidalorsen Treatment in Children With Hereditary Angioedema Hereditary Angioedema (HAE) | PHASE3 | Recruiting | 2029-06-01 |
| NCT05659901 ↗ | Rocket Study: A Study to Characterize Biomarkers and Disease Progression in Participants With Pelizaeus-Merzbacher Disease Pelizaeus-Merzbacher Disease | — | Recruiting | 2029-03-01 |
| NCT05127226 ↗ | HALOS: A Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Multiple Ascending Doses of ION582 in Participants With Angelman Syndrome Angelman Syndrome | PHASE1/PHASE2 | Recruiting | 2029-03-01 |
| NCT06150716 ↗ | Orbit Study: A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Intrathecally Administered ION356 in Participants With Pelizaeus Merzbacher Disease (PMD) Pelizaeus-Merzbacher Disease | PHASE1 | Recruiting | 2028-06-01 |
| NCT05130450 ↗ | A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Participants With Familial Chylomicronemia Syndrome (FCS) Familial Chylomicronemia Syndrome | PHASE3 | Active Not Recruiting | 2028-02-01 |
| NCT04165486 ↗ | Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ION464 Administered to Adults With Multiple System Atrophy (HORIZON) Multiple System Atrophy | PHASE1 | Recruiting | 2027-09-01 |
| NCT06430385 ↗ | ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS) Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome | PHASE1/PHASE2 | Recruiting | 2027-09-01 |
| NCT07604974 ↗ | A Study to Assess the Safety, Tolerability and Efficacy of ION775 Hypertriglyceridemia, Severe Hypertriglyceridemia | PHASE2 | Recruiting | 2027-09-01 |
| NCT06914609 ↗ | REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome Angelman Syndrome | PHASE3 | Recruiting | 2027-08-01 |
| NCT05185843 ↗ | A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRX) Administered to Adults With Familial Chylomicronemia Syndrome (FCS) Previously Treated With Volanesorsen Familial Chylomicronemia Syndrome | PHASE3 | Active Not Recruiting | 2027-06-01 |
| NCT05681351 ↗ | CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG) Severe Hypertriglyceridemia | PHASE3 | Active Not Recruiting | 2027-03-01 |
| NCT06153966 ↗ | PrProfile: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ION717 Prion Disease | PHASE1/PHASE2 | Recruiting | 2027-02-01 |
| NCT05392114 ↗ | A Study to Assess the Long-Term Safety and Efficacy of Donidalorsen in the Prophylactic Treatment of Hereditary Angioedema (HAE) Hereditary Angioedema | PHASE3 | Active Not Recruiting | 2026-12-01 |
| NCT04768972 ↗ | FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS) Amyotrophic Lateral Sclerosis | PHASE3 | Active Not Recruiting | 2026-06-01 |
| NCT04136171 ↗ | CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM) Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM) | PHASE3 | Active Not Recruiting | 2026-04-01 |
| NCT06073574 ↗ | CARDIO-TTRansform Magnetic Resonance Imaging (MRI) Sub-study Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM) | — | Active Not Recruiting | 2026-03-01 |
| NCT06073587 ↗ | The CARDIO-TTRansform Scintigraphy Sub-study Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM) | — | Active Not Recruiting | 2026-03-01 |
Source: ClinicalTrials.gov (U.S. NIH) · active studies first.
Supply chain
Customers (4)
- AstraZeneca
- Biogen
- PTC Therapeutics International Limited (PTC)
- Swedish Orphan Biovitrum AB (Sobi)
Suppliers (0)
Named in the 10-K; linked when we track them.
Notable events (8-K)
| Date | Items | |
|---|---|---|
| 2026-06-24 | Reg FDOtherExhibits | filing ↗ |
| 2026-06-12 | OtherExhibits | filing ↗ |
| 2026-06-08 | Exec/director changeShareholder voteReg FDExhibits | filing ↗ |
| 2026-05-28 | Reg FDOtherExhibits | filing ↗ |
| 2026-04-29 | ResultsExhibits | filing ↗ |
| 2026-04-21 | Reg FDOtherExhibits | filing ↗ |
| 2026-03-09 | Exec/director changeReg FDExhibits | filing ↗ |
| 2026-02-25 | ResultsExhibits | filing ↗ |
Recent filings
| Form | Filed | Period | Accession |
|---|---|---|---|
| 8-K | 2026-06-24 | 2026-06-24 | 0001140361-26-026232 ↗ |
| 8-K | 2026-06-12 | 2026-06-12 | 0001140361-26-025050 ↗ |
| 8-K | 2026-06-08 | 2026-06-04 | 0001140361-26-024407 ↗ |
| 8-K | 2026-05-28 | 2026-05-28 | 0001140361-26-023093 ↗ |
| 10-Q | 2026-04-29 | 2026-03-31 | 0000874015-26-000177 ↗ |
| 8-K | 2026-04-29 | 2026-04-29 | 0001140361-26-017637 ↗ |
| 8-K | 2026-04-21 | 2026-04-21 | 0001140361-26-015801 ↗ |
| 8-K | 2026-03-09 | 2026-03-03 | 0001140361-26-008340 ↗ |
| 10-K | 2026-02-26 | 2025-12-31 | 0000874015-26-000115 ↗ |
| 8-K | 2026-02-25 | 2026-02-25 | 0001140361-26-006718 ↗ |
| 8-K | 2026-01-12 | 2026-01-12 | 0001140361-26-000893 ↗ |
| 8-K | 2026-01-07 | 2026-01-07 | 0001140361-26-000435 ↗ |